7563-05-5

Upstream product

• 57224-51-8 N-benzoyl-2-methylalanine 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 74-88-4 methyl iodide 
• 54930-66-4 N-<1-(N,N-Dimethylcarbamoyl)-1-methylethyl>benzamid 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 541-41-3 chloroformic acid ethyl ester 
• 62-57-7 2-Aminoisobutyric acid 
• 2198-64-3 N-Benzoylalanine 

Downstream Products

• 120728-59-8 α-benzoylamino-isobutyric acid anilide 
• 37557-72-5 3-benzamido-3-methylbutan-2-one 
• 33149-81-4 2-(2-Benzoylamino-2-methyl-propionylamino)-propionic acid ethyl ester 
• 42930-55-2 2-(2-Benzoylamino-2-methyl-propionylamino)-butyric acid ethyl ester 
• 42930-58-5 2-(2-Benzoylamino-2-methyl-propionylamino)-3-methyl-butyric acid ethyl ester 
• 42930-59-6 2-(2-Benzoylamino-2-methyl-propionylamino)-4-methyl-pentanoic acid ethyl ester 
• 42930-56-3 2-(2-Benzoylamino-2-methyl-propionylamino)-2-methyl-propionic acid ethyl ester 
• 42930-60-9 2-(2-Benzoylamino-2-methyl-propionylamino)-3-phenyl-propionic acid ethyl ester 
• 42930-57-4 2-(2-Benzoylamino-2-methyl-propionylamino)-pentanoic acid ethyl ester 
• 870095-52-6 N-(2-hydroxy-1,1-dimethyl-2,2-diphenyl-ethyl)-benzamide 
• 42930-54-1 N-(α-benzoylamino-isobutyryl)-glycine ethyl ester 
• 62-57-7 2-Aminoisobutyric acid 
• 54016-23-8 N-(1-Carbamoyl-1-methylethyl)benzamid 
• 1192017-87-0 N-(1-(methoxy(methyl)amino)-2-methyl-1-oxopropan-2-yl)benzamide 

Relevant academic research and scientific papers

BEMP-promoted C(4)-alkylation of 4-alkyloxazol-5(4 H)-ones: A rapid and efficient route to α,α-dialkyl-α-amino acids

Rapid and efficient C(4)-alkylation of 4-alkyloxazol-5(4H)-ones has been achieved by the utilization of BEMP as base. 4,4-Dialkyloxazol-5(4H)-ones, which can easily be hydrolyzed into free α,α-dialkyl-α-amino acids, were obtained in high yields (up to 99%

DAST-mediated cyclization of α,α-disubstituted-α- acylaminoketones: Efficient and divergent synthesis of unprecedented heterocycles

The design of a new potent nonsteroidal ecdysone agonist led to the discovery of a diethylaminosulfur trifluoride (DAST)-mediated cyclization of α,α-disubstituted-α-acylaminoketones. The resulting fluorooxazolines can be ring-opened or selectively substit

Solid-phase de novo synthesis of a (±)-2-deoxy-glycoside

The solid-phase synthesis of methyl 2-deoxy-3-O-benzyl-d,l-arabino-hexopyranoside was achieved in a six-step sequence via a de novo strategy based on the hetero-Diels-Alder reaction of a vinyl ether supported on an azalactone-functionalized polystyrene re

NOVEL MICROBIOCIDES

Compounds of formula (I), in which the substituents are as defined in claim 1, are suitable for use as microbiocides.

SYNTHESIS OF α-SUBSTITUTED α-AMINO ACIDS BY THE ALKYLATION OF 5-OXAZOLINONE DERIVATIVES

Methods have been developed for the alkylation of 5-oxazolinone derivatives in DMF in the presence of K2CO3, KOH, or diisopropylethylamine and a phase transfer catalyst as well as for the preparation of α-methylphenylalanine, α-methylalanine, α-methylalanine, and the methyl ester of N-benzoyl-α-methylalanine.Increasing the initial concentration of the starting 5-oxazolinone in the reaction mixture leads to a sharp drop in the yield of reaction products due to side condensation reactions.The reaction of 2-phenyl-4-benzyl-5-oxazolinonewith ethyl iodide gave a dimer, mamely, 3-(benzoylamino)-3,5-dibenzylpyrrolidine-2,4-dione.

3-(Dimethylamino)-2,2-dimethyl-2H-azirine as an Aib Equivalent; Synthesis of Aib Oligopeptides

3-(Dimethylamino)-2,2-dimethyl-2H-azirine (1) reacts with carboxylic acids at 0-25 degC to give 2-acylamino-N,N,2-trimethylpropionamides (=2-acylamino-N,N-dimethylisobutyramide, acyl-Aib-NMe2) in excellent yields (Scheme 2 and 3).Examples of α-amino-, α-h

Synthesis of 4,4-Disubstituted 1,3-Thiazol-5(4H)-thiones

An easy synthesis for the 1,3-thiazol-5(4H)-thiones 5, a class of heterocycles which have hitherto only been available with difficulty, is described.Reaction of 3-amino-2H-azirines 25 with thiocarboxylic acids at 0 deg yields monothiodiamides of type 20 (Scheme 6) which, on treatment with Lawesson reagent at 100 deg, undergo thiation and cyclization to give 5 in good yield.

REACTIONS OF 2-PHENYL-4,4-DIMETHYL-2-OXAZOLIN-5-ONE AND 2-PHENYL-4-ETHYL-2-OXAZOLIN-5-ONE with KO2 IN APROTIC SOLVENTS

The reactions of 2-phenyl-4,4-dimethyl-2-oxazolin-5-one (I) and 2-phenyl-4-ethyl-2-oxazolin-5-one (II) with KO2 in tetrahydrofuran and freon are studied.Superoxide reacts with I to yield the N-benzoyl-α-aminoacid ring-opening product, indicating that O2 produces a nucleophilic attack at the carbonyl group of the oxazolinone.The oxazolinone II yields, in addition to the N-benzoyl-α-amino derivative, N-propanoyl benzamide (III) as the main reaction product.The results strongly suggest that III is formed after O2 has abstracted a proton from II, and then, species resulting from secondary reactions, such as oxygen, attack II to yield the final products.Several mechanistic pathways are discussed.