78015-36-8

Upstream product

• 94-09-7 p-aminoethylbenzoate 
• 13142-97-7 N-(p-ethoxycarbonylphenyl)-N'-phenylurea 
• 201230-82-2 carbon monoxide 
• 100-01-6 4-nitro-aniline 
• 124-38-9 carbon dioxide 
• 64-10-8 phenyl carbamate 
• 57-13-6 urea 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 150-13-0 4-amino-benzoic acid 
• 530-62-1 1,1'-carbonyldiimidazole 

Relevant academic research and scientific papers

Urea-containing metal-organic frameworks as heterogeneous organocatalysts

Two novel pillared metal-organic frameworks (MOFs) containing a urea-functional group are introduced. Herein, the urea functional group was incorporated into the MOF backbone by preparing a urea-ditopic ligand. These frameworks (TMU-18 and TMU-19) were fabricated using the synthesized urea-containing ligand, 4,4′-bipyridine (bipy) and 1,2-bis(4-pyridyl)ethane (bpe), and using zinc nitrate as the metal source. Subsequently, TMU-18 and TMU-19 were characterized by X-ray diffraction, IR spectroscopy, elemental analysis, scanning electron microscopy (SEM) and thermogravimetric analysis. Furthermore, their potential efficiency as organocatalysts was evaluated in the regioselective methanolysis of epoxides.

Hydrosilane-Assisted Synthesis of Urea Derivatives from CO2and Amines

A methodology employing CO2, amines, and phenylsilane was discussed to access aryl- or alkyl-substituted urea derivatives. This procedure was characterized by adopting hydrosilane to promote the formation of ureas directly, without the need to prepare silylamines in advance. Control reactions suggested that FeCl3 was a favorable additive for the generation of ureas, and this 1,5,7-triazabicyclo[4.4.0]dec-5-ene-catalyzed reaction might proceed through nucleophilic addition, silicon migration, and the subsequent formal substitution of silylcarbamate.

Sulfated polyborate-catalyzed efficient and expeditious synthesis of (un)symmetrical ureas and benzimidazolones

The excellent catalytic potential of sulfated polyborate is utilized in the synthesis of (un)symmetrical ureas and benzimidazolones by heating amines or substituted OPDA and urea or N-phenylureas under a solvent-free condition at 120 °C is described. The key advantages of the present protocol are phosgene-free, and other hazardous reagents or organic solvent free, high reaction rates and yields, simple workup procedure, and recyclability of the catalyst.

Urea Metal-Organic Frameworks for Nitro-Substituted Compounds Sensing

Urea groups are known to form strong hydrogen bonds with molecules containing atom(s) that can act as hydrogen bond acceptor(s). Thus, urea is a particularly interesting building block for designing receptors for neutral or charged guests. In the quest for new sensors with enhanced performance for the detection of nitro-substituted compounds, two pillared metal-organic frameworks containing urea functional groups were synthesized and structurally characterized. The sensing properties of these frameworks toward nitro-analytes were investigated and compared to each other. The study clearly reveals the importance of urea groups orientation inside the pore cavity of MOFs, as well as the supramolecular interactions between the interpenetrated networks. This work is interesting as it represents the first example of urea-functionalized MOFs for nitro-analytes recognition.

Catalytic oxidative carbonylation of arylamines to ureas with W(CO) 6/I2 as catalyst

The oxidative carbonylation of aniline to N,N'-diphenylurea was carried out by using W(CO)6 as the catalyst, I2 as the oxidant, CO as the carbonyl source and 4-(dimethylamino)pyridine (DMAP) as base. The reaction conditions were optimized with respect to different bases, molar ratio of DMAP/iodine, temperature, time, and CO pressure. Various p-substituted arylamines can be converted into the respective symmetrical and unsymmetrical N,N'-disubstituted ureas in moderate to good yields. The reaction demonstrated broad tolerance of functionality.

ARYL UREA DERIVATIVES

A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment.

Palladium-catalyzed reaction of aryl halides with ureas

A new method for the palladium-catalyzed arylation of ureas is described. The coupling reaction of urea and phenylurea with aryl halides containing electron-withdrawing groups in the p-position in dioxane in the presence of 0.5-1.0 mol% of Pd2dba3·CHCl3, Xantphos and Cs2CO3 as a base gives N,N′-diarylureas in yields of 64-92%.