78025-99-7

Upstream product

• 74-96-4 ethyl bromide 
• 59276-37-8 3,4,5-trimethoxybenzaldehyde dimethyl acetal 
• 78025-98-6 3,5-dimethoxy-4-ethylbenzonitrile 
• 2040-04-2 2,6-dimethoxyacetophenone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 75-03-6 ethyl iodide 
• 4433-63-0 Ethyl boronic acid 
• 31558-40-4 4-bromo-3,5-dimethoxybenzaldehyde 
• 78025-96-4 1-bromo-3-ethyl-2,4-dimethoxybenzene 
• 78025-97-5 4-ethyl-3,5-dimethoxy-aniline 
• 18610-90-7 1,3-dimethoxy-2-ethylbenzene 
• 140464-73-9 5-dimethoxymethyl-2-ethyl-1,3-dimethoxy-benzene 

Downstream Products

• 204649-95-6 (4-Ethyl-3,5-dimethoxy-benzyl)-dimethyl-amine 
• 204650-29-3 (E)-2-ethyl-5-(2-methylsulphanyl-2-methylsulphinyl-vinyl)-1,3-dimethoxybenzene 
• 141509-19-5 (E)-2-ethyl-1,3-dimethoxy-5-(2-phenylethenyl)benzene 
• 204650-30-6 methyl 2-(4-ethyl-3,5-dimethoxyphenyl)acetate 
• 204650-33-9 3-(4-ethyl-3,5-dimethoxy-phenyl)-1-methyl-piperidin-4-one 
• 204650-19-1 6-Ethyl-5,7-dimethoxy-3-nitromethyl-3H-isobenzofuran-1-one 
• 204650-34-0 ethyl (RS,E)-[3-(4-ethyl-3,5-dimethoxyphenyl)-1-methylpiperidin-4-ylidene]acetate 
• 204649-97-8 6-Dimethylaminomethyl-3-ethyl-2,4-dimethoxy-benzoic acid ethyl ester 
• 78026-01-4 2,4-diamino-5-(4'-ethyl-3',5'-dimethoxybenzyl)pyrimidine 
• 1351593-66-2 7-ethoxy-4-(4-ethyl-3,5-dimethoxybenzyl)isoquinolin-8-ol 
• 203579-18-4 4-ethyl-3,5-dimethoxybenzyl alcohol 

Relevant academic research and scientific papers

Identification of novel non-nucleoside vinyl-stilbene analogs as potent norovirus replication inhibitors with a potential host-targeting mechanism

Norovirus (NV), is the most common cause of acute gastroenteritis worldwide. To date, there is no specific anti-NV drug or vaccine to treat NV infections. In this study, we evaluated the inhibitory effect of different stilbene-based analogs on RNA genome replication of human NV (HNV) using a virus replicon-bearing cell line (HG23). Initial screening of our in-house chemical library against NV led to the identification of a hit containing stilbene scaffold 5 which on initial optimization gave us a vinyl stilbene compound 16c (EC50 = 4.4 μM). Herein we report our structure-activity relationship study of the novel series of vinyl stilbene analogs that inhibits viral RNA genome replication in a human NV-specific manner. Among these newly synthesized compounds, several amide derivatives of vinyl stilbenes exhibited potent anti-NV activity with EC50 values ranging from 1 to 2 μM. A trans-vinyl stilbenoid with an appended substituted piperazine amide (18k), exhibited potent anti-NV activity and also displayed favorable metabolic stability. Compound 18k demonstrated an excellent safety profile, the highest suppressive effect, and was selective for HNV replication via a viral RNA polymerase-independent manner. Its potential host-targeting antiviral mechanism was further supported by specific activation of heat shock factor 1-dependent stress-inducible pathway by 18k. These results suggest that 18k might be a promising lead compound for developing novel NV inhibitors with the novel antiviral mechanism.

Asymmetric total synthesis of (+)-: O -methylasparvenone, a rare nitrogen-free serotonin 2C receptor antagonist

The first enantioselective synthesis of the fungal metabolite (+)-O-methylasparvenone was achieved in eight steps and 22% overall yield from inexpensive 3,4,5-trimethoxybenzaldehyde dimethyl acetal. Key steps include (i) early-stage asymmetric alkynylation of an aromatic aldehyde with a propiolate, (ii) intramolecular Friedel-Crafts acylation, and (iii) site-selective cleavage of an aryl methyl ether.

SUBSTITUTED ISOQUINOLINES AND THEIR USE AS TUBULIN POLYMERIZATION INHIBITORS

The present invention relates generally to substituted isoquinolines and their use as tubulin polymerization inhibitors. In particular, the invention relates to substituted isoquinolines which possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds

Synthesis of antibiotic stilbenes by reductive metalation of 3,4,5-trimethoxybenzaldehyde dimethyl acetal

Reductive metalation of 3,4,5-trimethoxybenzaldehyde dimethyl acetal followed by reaction with suitable electrophiles is the key step of a reaction sequence leading to the synthesis of naturally occurring 4-alkyl-3,5-dihydroxy-substituted trans-stilbenes

Regioselective Reductive Alkylation of 3,4,5-Trimethoxybenzaldehyde Dimethylacetal: A New Synthesis of 4-Alkyl-3,5-dimethoxybenzaldehydes and 2,5-Dialkyl-1,3-dimethoxybenzenes

The regioselective replacement of the 4-methoxy group of 3,4,5-trimethoxybenzaldehyde dimethylacetal by an alkyl group under reductive electron-transfer conditions has been employed as a key step in a new synthesis of 2,5-dialkyl-1,3-dimethoxybenzenes via the corresponding 4-alkyl-3,5-dimethoxybenzaldehydes.