7803-65-8

Basic information

• Product Name: Ammonium hypophosphite
• Synonyms: hypophosphorousacid,ammoniumsalt;AMMONIUM HYPOPHOSPHITE;AMMONIUM PHOSPHINATE;AMMONIUM HYPOPHOSPHITE EXTRA PURE;Phosphinic acid, ammonium salt;AMMONIUM HYPOPHOSPHITE, 97%, FOR ANALYSIS;Ammonium hypophosphite, for analysis;Ammonium phosphenite
• CAS NO: 7803-65-8
• Molecular Formula: H₃N*H₃O₂P
• Molecular Weight: 83.03
• EINECS: 232-266-0
• Product Categories: Ammonium;Ammonium Salts;Chemical Synthesis;Inorganic Salts;Materials Science;Metal and Ceramic Science;Salts;Synthetic Reagents
• Mol File: 7803-65-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 155-160 °C
• Appearance: /white hygroscopic crystals
• Density: 1.634 [CRC10]
• Water Solubility: 1000 g/L
• Merck: 13,530
• CAS DataBase Reference: Ammonium hypophosphite(CAS DataBase Reference)
• NIST Chemistry Reference: Ammonium hypophosphite(7803-65-8)
• EPA Substance Registry System: Ammonium hypophosphite(7803-65-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 7803-65-8(Hazardous Substances Data)

Usage

Chemical Properties

white crystals

Uses

As catalyst in polyamide manufacture.

General Description

White crystalline solid. Sinks and mixes with water.

Air & Water Reactions

Water soluble. Ammonium hypophosphite liberates spontaneously flammable phosphine at about 240°C [Mellor 8:880 1946-47].

Reactivity Profile

Ammonium hypophosphite liberates spontaneously flammable phosphine at about 240°C [Mellor 8:880 1946-47]. Some inorganic materials, such as hypophosphites, tend to form explosive mixtures with perchloric acid when hot [Analyst 84:215 1959].

Hazard

Evolves flammable and toxic fumes on heating.

Health Hazard

Non-toxic or low toxicity unless heated to decomposition (240°C).

Flammability and Explosibility

Notclassified

Purification Methods

Crystallise it from hot EtOH.

InChI:InChI=1/H3N.HO2P/c;1-3-2/h1H3;(H,1,2)

Synthetic route

ammonium hydroxide + hypophosphorous acid (6303-21-5) → ammonium phosphinate (7803-65-8)

Conditions	Yield
In water 50% H3PO2 slowly added to 26% aq. ammonia; soln. evapd., residue dissolved in hot MeOH, cooled, ether added with stirring, after a few hours ppt. filtered off and washed with ether, driedunder vac.;	82.3%

ammonium carbonate + barium hypophosphite → ammonium phosphinate (7803-65-8)

Conditions	Yield
filtration, recrystn. from water or alc.;

ammonium carbonate + hypophosphorous acid (6303-21-5) → ammonium phosphinate (7803-65-8)

Conditions	Yield
filtration, recrystn. from water or alc.;

ammonium carbonate + calcium bis(hypophosphite) (7789-79-9) → ammonium phosphinate (7803-65-8)

Conditions	Yield
filtration, recrystn. from water or alc.;

ammonium sulfate + barium hypophosphite → ammonium phosphinate (7803-65-8)

phosphorus (12185-10-3) → ammonium phosphinate (7803-65-8) + phosphan (7803-51-2)

Conditions	Yield
With ammonia In water reacting with aq. NH3 in H2 flow;
With NH3 In water reacting with aq. NH3 in H2 flow;

ammonium sulfate + calcium bis(hypophosphite) (7789-79-9) → ammonium phosphinate (7803-65-8)

ammonium phosphinate (7803-65-8) → ammonium dihydrogenphosphite (13446-12-3)

Conditions	Yield
In hydrogenchloride byproducts: ammonium phosphate; Electrochem. Process; electrochemical oxidn. of hypophosphite at temp. 35-70°C; detn dy titrn.;	83%

ammonium phosphinate (7803-65-8) + (Me4N)3{Ir(III)(trichlorostannide)5Cl} → 2NH4(1+)*IrSn5(13+)*5H2PO2(1-)*5OH(1-)*5Cl(1-) = (NH4)2[IrSn5(H2PO2)5(OH)5Cl5]

Conditions	Yield
In water mixed, stirred for 30 min, pptd.; ppt. washed (alcohol, ether), elem. anal., IR, MOE;	80%

ammonium phosphinate (7803-65-8) + nickel(II) chloride hexahydrate → NH4(1+)*Ni(2+)*3H2PO2(1-)*H2O=NH4[Ni(H2PO2)3(H2O)]

Conditions	Yield
In methanol solns. of (NH4)H2PO2 and NiCl2 in CH3OH mixed, soln. allowed to evap. onair; green blocks firstly crystd. turn into yellow-green plates of desi red compd. after 1 week; crystals isolated and washed with EtOH and acetone; elem. anal.;	78.2%

ammonium phosphinate (7803-65-8) + manganese(II) chloride tetrahydrate → manganese hypophosphite monohydrate + NH4(1+)*Mn(2+)*3H2PO2(1-)*H2O=NH4[Mn(H2PO2)3(H2O)]

Conditions	Yield
In methanol; water; acetone solns. of (NH4)H2PO2 and MnCl2 in CH3OH mixed, water added, soln. layered with acetone; two-layer-system stored for 1 week, crystals sepd. manually; elem. anal.;	A n/a B 74.3%

ammonium phosphinate (7803-65-8) + cobalt(II) chloride hexahydrate → hexaaquacobalt(II) bis(hypophosphite)

Conditions	Yield
In water; acetone aq. soln. of CoCl2 and NH4H2PO4 layered with acetone, system stored for 5 d; crystals collected;	72.5%

ammonium phosphinate (7803-65-8) + [Mo3(sulfido)4(aqua)9](4+) (101660-28-0) + nickel(II) chloride hexahydrate + cucurbituril (80262-44-8) → trihydroxophosphinenickeloctaaquachlorotetrasulfidotrimolybdenum trichloride cucurbit[6]uril tridecahydrate

Conditions	Yield
With glycerol In hydrogenchloride addn. of NiCl2*6H2O (10-fold excess) and NH4H2PO2 to soln. of (Mo3S4(H2O)9(4+) in 2 M HCl; stirring under Ar at 60°C for 24 h; concn., addn. of cucurbit(6)uril in 1 M HCl and glycerol (10 drops); keeping at room temp. for 1 week; crystn., elem. anal.;	72%

ammonium phosphinate (7803-65-8) + cobalt(II) chloride hexahydrate → NH4(1+)*Co(2+)*3H2PO2(1-)*H2O=NH4[Co(H2PO2)3(H2O)]

Conditions	Yield
In methanol; water solns. of (NH4)H2PO2 and CoCl2 in CH3OH mixed, water added, soln. allowed to evap. on air; crystals isolated; elem. anal.;	61.2%

ammonium phosphinate (7803-65-8) + (Me4N)4{Ru(II)(trichlorostannide)5Cl} → 3NH4(1+)*RuSn5(12+)*5H2PO2(1-)*5OH(1-)*5Cl(1-) = (NH4)3[RuSn5(H2PO2)5(OH)5Cl5]

Conditions	Yield
In water mixed, treated with 3M HCl, pptd.; ppt. washed (alcohol, ether), dried (vac., KOH), elem. anal., IR, MOE;	70-80

ammonium phosphinate (7803-65-8) + (Me4N)3{platinum(II)(trichlorostannide)5} → 3NH4(1+)*PtSn5(12+)*5H2PO2(1-)*5OH(1-)*5Cl(1-) = (NH4)3[PtSn5(H2PO2)5(OH)5Cl5]

Conditions	Yield
In water mixed, treated with 3M HCl, pptd.; ppt. washed (alcohol, ether), dried (vac., KOH), elem. anal., MOE, IR;	70-80

ammonium phosphinate (7803-65-8) → phosphorus suboxide

Conditions	Yield
With acetic anhydride In acetic acid reaction of a soln. of 30 g crystalline NH4H2PO2 in 50-100 g glacial acetic acid with 90 g acetic anhydride;;
With acetic anhydride In acetic acid reaction of a soln. of 30 g crystalline NH4H2PO2 in 50-100 g glacial acetic acid with 90 g acetic anhydride;;

ammonium phosphinate (7803-65-8) → ammonia (7664-41-7) + phosphan (7803-51-2)

Conditions	Yield
In neat (no solvent) byproducts: H6P4O13{H4P2O7 +2HPO3}, H2O, H2; heating;
In neat (no solvent) byproducts: H6P4O13{H4P2O7 +2HPO3}, H2O, H2; heating;

uranyl(VI) nitrate + ammonium phosphinate (7803-65-8) → ammonium uranyl hypophosphite

Conditions	Yield
In not given crystn. from mixture of soln. of 1 mol uranyl nitrate and 6 up to 8 mol NH4-hypophosphite on concg. over H2SO4;;

ammonium phosphinate (7803-65-8) + strontium hydroxide → ammonium strontium orthophosphate

Conditions	Yield
In not given no formation of NH4SrPO4 from soln. of Sr(OH)2 with NH4H2PO4-soln.;;	0%
In not given no formation of NH4SrPO4 from soln. of Sr(OH)2 with NH4H2PO4-soln.;;	0%

ammonium phosphinate (7803-65-8) + (Me4N)4{Os(II)(trichlorostannide)5Cl} → 3NH4(1+)*OsSn5(12+)*5H2PO2(1-)*5OH(1-)*5Cl(1-) = (NH4)3[OsSn5(H2PO2)5(OH)5Cl5]

Conditions	Yield
In water mixed, treated with 3M HCl, pptd.; ppt. washed (alcohol, ether), dried (vac., KOH), elem. anal., IR, MOE;	70-80

ammonium phosphinate (7803-65-8) + (Me4N)3{Rh(III)(trichlorostannide)5Cl} → 2NH4(1+)*RhSn5(13+)*5H2PO2(1-)*5OH(1-)*5Cl(1-) = (NH4)2[RhSn5(H2PO2)5(OH)5Cl5]

Conditions	Yield
In water mixed, treated with 3M HCl, pptd.; ppt. washed (alcohol, ether), dried (vac., KOH), elem. anal., MOE, IR;	70-80

ammonium phosphinate (7803-65-8) + 3(CH3)4N(1+)*Pd(SnCl3)5(3-)={(CH3)4N}3{Pd(SnCl3)5} → 2NH4(1+)*Pd(2+)*4Sn(2+)*4(OH)(1-)*4Cl(1-)*4H2PO2(1-) = (NH4)2[Pd(Sn(OH)Cl)4(H2PO2)4]

Conditions	Yield
In water mixed, treated with 3M HCl, pptd.; ppt. washed (alcohol, ether), dried (vac., KOH), elem. anal., MOE, IR;	70-80

Upstream product

• 7664-41-7 ammonia 
• 6303-21-5 hypophosphorous acid 
• 7789-79-9 calcium bis(hypophosphite) 
• 12185-10-3 phosphorus 
• 1336-21-6 ammonium hydroxide 

Downstream Products

• 26508-33-8 iron monophosphide 
• 7664-41-7 ammonia 
• 7803-51-2 phosphan 
• 13446-12-3 ammonium dihydrogenphosphite 

Relevant articles and documents

Syntheses, structures and magnetic properties of zig-zag chains of transition metals with O-P-O bridges

A novel series of linear chain coordination polymers, [NH4][MII(H2PO2)3(H2O)] where M = Mn, Co, Ni, has been obtained by the reaction of divalent metals salts with ammonium pyrophosphite, [

SH2 domain binding inhibitors

Disclosed are compounds represented by the formula: [image] or a pharmaceutically acceptable salt or isomer thereof, wherein R1-R6 are as defined in the specification. These compounds are targeted for use as inhibitors of SH2 domain binding with a phosphoprotein, and are contemplated for use in a number of diseases including cancer. Also disclosed are pharmaceutical compositions comprising a compound of the invention and a pharmaceutically acceptable carrier.