78032-28-7

Upstream product

• 603-35-0 triphenylphosphine 
• 64370-35-0 p-nitrobenzyl glyoxylate 
• 75939-02-5 Silver; (2R,3S)-3-ethyl-1-[(4-nitro-benzyloxycarbonyl)-(triphenyl-λ⁵-phosphanylidene)-methyl]-4-oxo-azetidine-2-thiolate 
• 75-36-5 acetyl chloride 

Downstream Products

• 78032-31-2 (+/-)-trans-6-ethyl-2-methyl-2-penem-3-carboxylic acid p-nitrobenzyl ester 

Relevant academic research and scientific papers

4-TETRAHYDROPYRANTHIOAZETIDINYL PHOSPHORANES: VERSATILE INTERMEDIATES IN THE SYNTHESIS OF 2-PENEMS

The total synthesis of four racemic trans-6-ethyl-2-penems has been developed using the 4-tetrahydropyranthioazetidinyl phosphorane 10 as a common precursor.

TOTAL SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 6-ETHYL-2-PENEM DERIVATIVES

The total synthesis of some racemic trans-6-ethyl-2-penem derivatives has been developed starting from the adducts obtained by the reaction of 3-ethyl-4-(p-toluenethio)azetidin-2-one S,S-dioxide with suitable thiolacids and thioenols.The derivatives have been tested in vitro and their comparative activities as minimal inhibitory concentration against a choice of microorganisms are reported.