78033-34-8

Basic information

• Product Name: benzyl (2-oxo-3-phenylacetamido-4-styryl-1-azetidinyl)malonate
• CAS NO: 78033-34-8
• Molecular Weight: 588.66
• Mol File: 78033-34-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: benzyl (2-oxo-3-phenylacetamido-4-styryl-1-azetidinyl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (2-oxo-3-phenylacetamido-4-styryl-1-azetidinyl)malonate(78033-34-8)
• EPA Substance Registry System: benzyl (2-oxo-3-phenylacetamido-4-styryl-1-azetidinyl)malonate(78033-34-8)

Safety Data

• Hazardous Substances Data: 78033-34-8(Hazardous Substances Data)

Upstream product

• 104-55-2 3-phenyl-propenal 
• 31661-15-1 dibenzyl aminomalonate 
• 107-21-1 ethylene glycol 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 78033-35-9 benzyl (4-hydroxymethyl-2-oxo-3-phenylacetamido-1-azetidinyl)malonate 
• 78033-36-0 (5R,6R)-7-Oxo-6-phenylacetylamino-3-oxa-1-aza-bicyclo[3.2.0]heptane-2,2-dicarboxylic acid dibenzyl ester 

Relevant articles and documents

Synthesis and biological evaluation of an electronically activated isooxacephem

New isooxacephem (±)-3-ethyl 2-hydrogen (6RS,7RS)-8-oxo-7-(phenylacetamido)-4-oxa-1-azabicyclo[4.2.0]oct-2-ene-2,3 -dicarboxylate (8) was synthesized from (±)-dibenzyl 2-[cis-2-oxo-3-(phenylacetamido)-4-styryl-1-azetidinyl]-2-[t -butyldimethylsiloxy(methoxycarbonyl)methyl]malonate (1) in six steps. This bicyclic β-lactam was found to possess notable biological activities against several pathogenic microorganisms in vitro, including Staphylococcus aureus 95, S. aureus FDA 209P, Escherichia coli ATCC 39188, Salmonella typhi O-901, Pseudomonas aeruginosa 18S-H, P. aeruginosa 1101-75, and Klebsiella pneumoniae NCTC 418. The electronic activation of the β-lactam moiety by an ester group plays a prominent role in the biological activity of this novel isooxacephem.

β-Lactams. VIII. The synthesis of iso-oxapenams from N-substituted-4-hydroxymethylazetidininons

The synthesis of 3,3-disubstituted iso-oxapenams is described.