78044-65-2

Upstream product

• 78044-61-8 ethyl (S)-2-acetyl-5-chloro-2-methyl-4-hexenoate 
• 78044-62-9 ethyl (S)-2-acetyl-2-methyl-5-oxohexanoate 
• 1012796-77-8 C₁₆H₂₄O₇ 
• 141-52-6 sodium ethanolate 
• 116831-04-0 (R)-2-acetyl-2-methyl-5-oxohexanoic acid ethyl ester 
• 78044-60-7 ethyl (2S)-5-chloro-2((S)-1-hydroxyethyl)-2-methyl-4-hexenoate 
• 193468-16-5 (2Z)-(+)-ethyl 2-methyl-3-[(S)-α-methylbenzylamino]-2-butenoate 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 27372-03-8 (3S)-3-Hydroxy-2-methylbutansaeure-ethylester 

Relevant academic research and scientific papers

A general and highly selective chelate-controlled intermolecular oxidative heck reaction

A novel chelate-controlled intermolecular oxidative Heck reaction is reported that proceeds with a wide range of nonresonance stabilized α-olefin substrates and organoboron reagents to afford internal olefin products in good yields and outstanding regio- and E:Z stereoselectivities. Pd-H isomerization, common in many Heck reactions, is not observed under these mild, oxidative conditions. This is evidenced by outstanding E:Z selectivities (>20:1 in all cases examined), no erosion in optical purity for proximal stereogenic centers, and a tolerance for unprotected alcohols. Remarkably, a single metal/ligand combination, Pd/bis-sulfoxide complex 1, catalyzes this reaction over a broad range of coupling partners. Given the high selectivities and broad scope, we anticipate this intermolecular Heck reaction will find heightened use in complex molecule synthesis. Copyright

Stereoselective synthesis of highly enantioenriched 3-methyl-2-cyclohexen-1-ones possessing an asymmetric quaternary carbon as C-4 or C-6: a sugar template approach

The 1,4-addition of the enolate generated from α-methylated acetoacetate incorporated at C-4 of methyl 6-deoxy-2,3-di-O-(tert-butyldimethylsilyl)-α-d-glucopyranoside to methyl vinyl ketone, followed by aldol condensation of the resulting 1,4-addition prod

MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF

Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-?B activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or an enantiomer, a diastereomer, a pharmaceutically acceptable salt, or hydrate thereof, where J is selected from NR1 or C(R4)(R4a); K is selected from NR2 or C(R5)(R5a); L is selected from NR3 or C(R6)(R6a); and A, X, Y, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R8, R10, R11, and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

Michael reaction of acyclic β-enaminoesters derived from α-alkyl-β-ketoesters and chiral α-methylbenzylamine: Stereoselective generation of quaternary carbon centres

Michael reaction of electrophilic olefins with acyclic β-enaminoester substrates derived from α-substituted β-ketoesters and (R)- or (S)-α-methylbenzylamine under neutral conditions resulted in the enantioselective formation of quaternary centres. The add

THE STEREOSELECTIVE α-ALKYLATION OF CHIRAL β-HYDROXY ESTERS AND SOME APPLICATIONS THEREOF

The stereoselectivity of the α-alkylation of chiral β-hydroxy ester is discussed.The configuration of the alkylated product was proved chemically (Scheme 2) .A one pot aldol-alkylation reaction was developed leading stereoselectively to racemic(S*,S*)-α-alkyl-β-hydroxy ester (Scheme 3,4) .Baker's yeast reduction of 2-alkyl-3-keto ester led to valuable chiral (2RS,3S)-intermediates, which were converted via the corresponding dianion to compounds with a chiral quaternary C atom (Scheme 6) .Synthetic applications of the above findings are shown in the synthesis of various chiral compounds (Scheme 8 and 9) .

ON THE STEREOSELECTIVITY OF THE α-ALKYLATION OF Β-HYDROXY ESTERS. ENANTIOSELECTIVE SYNTHESIS OF 4,4- AND 6,6-DISUBSTITUTED CYCLOHEX-2-EN-1-ONES.

Stereoselective α-alkylation of the optically active β-hydroxyester 1 gives rise to 2, which was converted to the 1,5-diketone 4.Regioselective aldolcondensation of the latter furnished (S)-5 and (S)-6 respectively, each with an e.e. of 86percent.