780782-36-7

Upstream product

• 75-20-7 calcium carbide 
• 2043-61-0 cyclohexanecarbaldehyde 
• 103-49-1 dibenzylamine 
• 1066-54-2 trimethylsilylacetylene 
• 780782-32-3 (±)-N,N-dibenzyl-N-[1-cyclohexyl-3-(trimethylsilyl)-2-propynyl]amine 

Downstream Products

• 780782-52-7 (+/-)-4-cyclohexyl-4-(dibenzylamino)-1-(2-furyl)but-2-yn-1-one 
• 479543-22-1 N,N-dibenzyl-1-cyclohexyl-3-phenyl-2-propyn-1-amine 
• 1360788-80-2 N₁,N₁,N₄,N₄-tetrabenzyl-1,4-dicyclohexylbut-2-yne-1,4-diamine 

Relevant academic research and scientific papers

A 1,3-amino group migration route to form acrylamidines

A novel 1,3-amino group migration strategy for the synthesis of acrylamidines is presented. Cu(i) catalyzed reaction of N,N-disubstituted propargylamine with tosylazide generates a highly reactive ketenimine intermediate which is trapped by a tethered amino group leading to the rearrangement reaction.

Copper(I)-catalysed deacetylenative cross-coupling reaction of terminal alkynes with propargylic amines via C(sp)-C(sp3) bond cleavage

The catalytic deacetylenative coupling reaction of terminal alkynes with various N-substituted propargylic amines proceeded in the presence of CuCl (10 mol%) and NaPO(4 equiv) in THF at 130 °C to give the corresponding substituted propargylic amines in go

Synthesis of chiral α-aminoalkylpyrimidines using an enantioselective three-component reaction

A range of chiral α-aminoalkylpyrimidines has been prepared in a modular fashion in 5 steps with up to 98% ee. The key step is a CuBr-catalyzed enantioselective asymmetric three-component synthesis of propargylic amines.