78123-60-1

Basic information

• Product Name: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-L-valyl-, methyl ester
• CAS NO: 78123-60-1
• Molecular Formula: C26H41N3O6
• Molecular Weight: 491.628
• Mol File: 78123-60-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-L-valyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-L-valyl-, methyl ester(78123-60-1)
• EPA Substance Registry System: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-L-valyl-, methyl ester(78123-60-1)

Safety Data

• Hazardous Substances Data: 78123-60-1(Hazardous Substances Data)

Upstream product

• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 20902-47-0 N-tert-butoxycarbonyl-L-valyl-L-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 13734-41-3 t-Boc-L-valine 
• 39614-17-0 L-valyl-L-phenylalanine methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 63-91-2 L-phenylalanine 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 54199-87-0 Boc-(S)-Leucyl-(S)-valin 
• 72-18-4 L-valine 
• 4070-48-8 L-Valine methyl ester 
• 61-90-5 L-leucine 

Downstream Products

• 171858-47-2 (S)-2-Acetylamino-4-methyl-pentanoic acid ((S)-1-{(S)-1-benzyl-3-[(8S,11S)-8-((S)-sec-butyl)-7,10-dioxo-2-oxa-6,9-diaza-bicyclo[11.2.2]heptadeca-1⁽¹⁶⁾,13⁽¹⁷⁾,14-trien-11-ylamino]-2-oxo-propylcarbamoyl}-2-methyl-propyl)-amide 
• 171858-42-7 (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-1-diazo-3-phenylbutan-2-one 
• 148333-47-5 (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoic acid 
• 171858-43-8 (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-1-bromo-3-phenylbutan-2-one 
• 52828-91-8 H-Leu-Val-Phe-OMe 
• 902459-75-0 Boc-Leu-Val-Phe-OH 
• 171858-41-6 methyl (S)-2-<<(acetyl)-(S)-leucinyl-(S)-valinyl>amino>-3-phenylpropanoate 

Relevant articles and documents

A peptide based two component white light emitting system

A peptide based two component white light emitting system has been designed and developed on the basis of a co-assembly of a PDI containing peptide system as an acceptor and a stilbene containing peptide system as a donor in organic solvents.

Regioselective structural and functional mimicry of peptides. Design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease

Hydrolytically-stable cyclic mimetics of the tripeptides Leu-Asn-Phe and Phe-Ile-Val were designed and incorporated into peptidic inhibitors, Ac-{Leu-Asn-Phe}-CHOHCH2-Pro-Ile-Val-NH2 and Ac-Leu-Val-Phe-CHOHCH2-{Phe-Ile-Val}-NH2, of HIV-1 protease. Structural mimicry has been established through molecular modeling and X-ray crystallographic studies of inhibitors bound to HIV-1 protease. Cyclic and acyclic inhibitors had similar conformations that were superimposable and formed similar interactions with the enzyme. Functional mimicry was demonstrated by comparable inhibition of the protease by acyclic and cyclic molecules. Further substitution of the residual acyclic Pro-Ile-Val or Leu-Val-Phe inhibitor components, with Pip-NHtBu or Boc-Phe, respectively, gave hydrolytically stable, water-soluble, lipophilic inhibitors of similar potency. The use of cycles to fix the conformations of amino acid sequences in peptides allows regioselective structural mimicry leading to functional mimicry and also permits localized structure-activity optimization in inhibitors of HIV-1 protease. This approach might be usefully applied to inhibitors of other proteins.