78146-62-0Relevant academic research and scientific papers
Synthesis and Properties of 8-Nitro-7-Alkylated Theophylline Derivatives
Mosselhi, Mosselhi A. N.,Abbass, Ikhlass M.
, p. 179 - 186 (2007/10/02)
8-Nitrotheophylline (3) was alkylated with alkylhalides to obtain the corresponding 8-nitro-7-alkylated theophylline derivatives (4a-d).The reduction of 4a-d provided 8-aminoderivatives (5a-d).Heating 4a-d in the concentrated HCl gave the corresponding 8-chloroderivatives (6a-d).The products 5a and 5b reacted with 4-acetamidobenzenesulphonyl chloride to provide 8-(4'-acetamidobenzenesulphonamido)theophyllines (7a) and (7b).The acid hydrolysis of 7a and 7b gave the corresponding 8-(4'-aminobenzenesulphonamido)theophyllines (8a) and (8b), which were also products of the reaction of 6b and 6c with 4-acetamidobenzenesulphonamide, followed by the acid hydrolysis.The reaction of 6a and 6b with benzylamine in dimethylformamide resulted unexpectedly in the 8-dimethylaminoderivatives (9a) and (9b), respectively. Key words: 8-nitrotheophylline, alkylhalides, HCl, acid hydrolysis.
REACTIONS OF THEOPHYLLINES. SYNTHESIS OF 8-TRIMETHYLAMMONIOTHEOPHYLLINATE
Bobkov, V. N.,Zvolinskaya, T. V.,Kuz'menko, I. I.
, p. 1317 - 1322 (2007/10/02)
The reaction of 8-bromo- and 8-dimethylaminotheophyllines with organic acid chlorides in the presence of tertiary aliphatic amines was investigated. The direction of the reactions depends on the nature of each of the three components. Depending on the com
