781647-96-9

Basic information

• Product Name: (5-METHYL-2-NITRO-PHENYL)-PHENYL-METHANONE
• Synonyms: (5-METHYL-2-NITRO-PHENYL)-PHENYL-METHANONE
• CAS NO: 781647-96-9
• Molecular Formula: C₁₄H₁₁NO₃
• Molecular Weight: 241.24
• Mol File: 781647-96-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (5-METHYL-2-NITRO-PHENYL)-PHENYL-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYL-2-NITRO-PHENYL)-PHENYL-METHANONE(781647-96-9)
• EPA Substance Registry System: (5-METHYL-2-NITRO-PHENYL)-PHENYL-METHANONE(781647-96-9)

Safety Data

• Hazardous Substances Data: 781647-96-9(Hazardous Substances Data)

Usage

General Description

(5-Methyl-2-nitro-phenyl)-phenyl-methanone, also known as MNPM, is a chemical compound with the molecular formula C14H11NO3. It is a nitrophenyl ketone that consists of a phenyl ring with a methyl and nitro substituent at the 5th and 2nd position, respectively. MNPM is commonly used in the pharmaceutical industry as a key intermediate for the synthesis of various organic compounds and pharmaceutical products. It is also utilized in research and development processes for its unique structural and chemical properties, making it a valuable building block for the creation of novel compounds. Additionally, MNPM has potential applications in the field of organic chemistry and can be used as a versatile reagent for various synthetic transformations.

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 17852-28-7 2-amino-5-methylbenzophenone 
• 52263-96-4 N-(2-benzoyl-4-methylphenyl)benzamide 
• 117039-85-7 6-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 
• 781647-78-7 (2S,5R)-2-tert-butyl-5-(5-methyl-2-nitrophenyl)-5-phenyl-1,3-dioxolan-4-one 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 3113-72-2 5-methyl-2-nitrobenzoic acid 
• 71-43-2 benzene 
• 781647-90-3 (R)-5-methyl-2-nitrobenzilic acid 
• 81036-97-7 (2S,5S)-2-tert-butyl-5-phenyl-1,3-dioxolan-4-one 

Relevant articles and documents

Lactam Compound, Preparation Method and Use thereof

Provided is a lactam compound, a tautomer, a stereoisomer, a racemate, a nonequal mixture of enantiomers, a geometric isomer, a solvate, a pharmaceutically acceptable salt thereof, or a solvate of the salt of the compound, and a pharmaceutical composition containing the compound. Also provided are the use of such compounds and their pharmaceutical compositions as drugs, especially as antiviral drugs.

Highly diastereoselective arylation of (S)-mandelic acid enolate: Enantioselective synthesis of substituted (R)-3-hydroxy-3-phenyloxindoles and (R)-benzylic acids and synthesis of nitrobenzophenones

An easy access to substituted (R)-3-hydroxy-3-phenyloxindoles, (R)-benzylic acids, and benzophenones is described. The reaction of the lithium enolate of the (2S,5S)-cis-1,3-dioxolan-4-one derived from optically active (S)-mandelic acid and pivalaldehyde with several o- and p-halonitrobenzenes proceeds readily to give the corresponding arylation products in good yields and diastereoselectivities. The reduction of the nitro group with Zn/HCl/EtOH in the o-nitro arylation products with concomitant intramolecular aminolysis of the dioxolanone moiety leads directly to enantiomerically pure (R)-3-hydroxy-3- phenyloxindoles. On the other hand the basic hydrolysis of the dioxolanone moiety in all the arylation products (ortho and para) leads to enantiomerically pure substituted (R)-benzylic acids. The oxidative decarboxylation of these latter with oxygen as terminal oxidant in the presence of pivalaldehyde and the Co(III)-Me2opba complex as catalyst gives substituted nitrobenzophenones.