52263-96-4

Upstream product

• 36804-50-9 5-methyl-2,3-diphenyl-indole 
• 17852-28-7 2-amino-5-methylbenzophenone 
• 7647-01-0 hydrogenchloride 
• 77930-24-6 N,N-dibenzoyl(p-methylphenyl)amine 
• 98-88-4 benzoyl chloride 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 117039-85-7 6-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-one 
• 100-58-3 phenylmagnesium bromide 
• 106-49-0 p-toluidine 

Downstream Products

• 17852-28-7 2-amino-5-methylbenzophenone 

Relevant academic research and scientific papers

Lactam Compound, Preparation Method and Use thereof

Provided is a lactam compound, a tautomer, a stereoisomer, a racemate, a nonequal mixture of enantiomers, a geometric isomer, a solvate, a pharmaceutically acceptable salt thereof, or a solvate of the salt of the compound, and a pharmaceutical composition containing the compound. Also provided are the use of such compounds and their pharmaceutical compositions as drugs, especially as antiviral drugs.

Chiral Phosphoric Acid Catalyzed Kinetic Resolution of 2-Amido Benzyl Alcohols: Asymmetric Synthesis of 4H-3,1-Benzoxazines

An efficient method for the asymmetric synthesis of 4H-3,1-benzoxazines was developed by kinetic resolution of 2-amido benzyl alcohols using chiral phosphoric acid catalyzed intramolecular cyclizations. A broad range of benzyl alcohols (both secondary and tertiary alcohols) were kinetically resolved with high selectivities, with an s factor of up to 94. Mechanistic studies were performed to elucidate the mechanism of these reactions, wherein the amide moieties reacted as the electrophiles. Gram-scale reaction and facile transformations of the chiral products demonstrate the potential of this method in asymmetric synthesis of biologically active chiral heterocycles.