78179-02-9

Upstream product

• 78178-96-8 methyl bromopyruvate 2,4-dinitrophenylhydrazone 
• 40163-47-1 1-ethyl-2,3,4,6,7,12-hexahydro-indolo[2,3-a]quinolizine 
• 790-12-5 2-(2,4-dinitrophenylhydrazono)-propanoic acid 
• 3618-76-6 Brenztraubensaeure-methylester-(2,4-dinitro-phenylhydrazon) 
• 119-26-6 (2,4-dinitro-phenyl)-hydrazine 

Downstream Products

• 83289-22-9 methyl (+/-)-(1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate 
• 1617-90-9 vincamin 
• 6835-99-0 14-epivincamine 
• 83289-24-1 methyl (1α,12bα,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate 
• 83289-23-0 methyl (1β,12bβ,Z)-α-<(2,4-dinitrophenyl)hydrazono>-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo<2,3-a>quinolizine-1-propanoate 

Relevant academic research and scientific papers

Synthesis of vincaminic acid derivatives

Vincaminic acid derivatives of formula (A) STR1 useful in treating cerebral insufficiency, are prepared by reacting 1-ethyl-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizine with the 2,4-DNP hydrazone of ethyl or methyl bromopyruvate followed by (i) reduction of the C=N bond and (ii) simultaneous cyclization with removal of the ketone-protecting group in either order.