78242-79-2

Upstream product

• 42016-93-3 2-chloro-4-iodoaniline 
• 38762-41-3 2-chloro-4-bromoaniline 
• 411235-57-9 cyclopropylboronic acid 
• 878672-11-8 C₁₁H₁₂ClNO 
• 19936-11-9 N-(4-cyclopropylphenyl)acetamide 
• 3158-71-2 4-cyclopropylaniline 
• 871476-62-9 N-tert-butoxycarbonyl-2-chloro-4-cyclopropylaniline 
• 871476-61-8 tert-butyl (2-chloro-4-iodophenyl)carbamate 

Downstream Products

• 871477-11-1 C₁₀H₈ClNS 
• 78242-81-6 N-(2-chloro-4-cyclopropyl-phenyl)-S-methyl-isothiouronium iodide 
• 1169483-61-7 2-chloro-4-cyclopropyl-benzene-1-sulfonyl chloride 
• 1824708-16-8 1-(2-chloro-4-cyclopropylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid 

Relevant academic research and scientific papers

BENZOPIPERIDINE DERIVATIVE, PREPARATION METHOD THEREOF AND MEDICAL USE THEREOF

The present invention relates to a benzopiperidine derivative, a preparation method thereof and a medical use thereof. In particular, the present invention relates to a benzopiperidine derivative as shown by general formula (I), a preparation method thereof and a pharmaceutical composition containing the derivative, as well as a use thereof as an estrogen receptor modulator in the prevention and/or treatment of estrogen receptor-mediated or dependent diseases or conditions. Preferably, the disease is breast cancer. The substituents in the general formula (I) are the same as those defined in the description.

CARBOXAMIDE DERIVATIVES

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt or co-crystal thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

PHENYL ACETIC ACID DERIVATIVES AS INFLAMMATION MODULATORS

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of p

Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases

A series of aryl thiotetrazolylacetanilides were synthesized and found to be potent inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases. The incorporation of an alkynyl fragment on the aniline provided inhibitors with ex

S-TRIAZOLYL α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.

NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

The invention relates to compounds of formula (I) wherein Ar, X, R1, R2, R3 and R4 are as defined herein and, pharmaceutical compositions thereof useful, either alone or in combination with other therapeutic agents as reverse transcriptase inhibitors against wild type and single or double mutant strains of HIV for the treatment or prophylaxis of HIV infection

Aminopyrroline compounds

Compound of formula (I): in which: n is 1 or 2, X represents alkylene, alkenylene, alkynylene or optionally substituted arylene or heteroarylene, R10represents hydrogen or alkyl and R11and R12together form a bond, or alternatively R12represents hydrogen or alkyl and R10and R11together form a bond, R2, R3and R4each independently of the others represents hydrogen, alkyl, hydroxyalkyl, alkoxy, alkoxycarbonyl, aryl, arylalkyl or aryloxyalkyl, or two of R2, R3and R4form a cycloalkyl radical. Medicinal products containing the same are useful in the treatment of cardiovascular diseases.