782450-79-7Relevant academic research and scientific papers
Convergent synthesis of a complex oxime library using chemical domain shuffling
Su, Shun,Acquilano, Dayle E.,Arumugasamy, Jeevanandam,Beeler, Aaron B.,Eastwood, Erin L.,Giguere, Joshua R.,Lan, Ping,Lei, Xiaoguang,Min, Geanna K.,Yeager, Adam R.,Zhou, Ya,Panek, James S.,Snyder, John K.,Schaus, Scott E.,Porco Jr., John A.
, p. 2751 - 2754 (2007/10/03)
(Chemical Equation Presented) The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.
Synthesis of complex alkoxyamines using a polymer-supported N-hydroxyphthalimide
Su, Shun,Giguere, Joshua R.,Schaus, Scott E.,Porco Jr., John A.
, p. 8645 - 8657 (2007/10/03)
The synthesis of a polymer-supported N-hydroxyphthalimide is described. The polystyrene-bound N-hydroxyphthalimide resin 1 has been used to prepare complex alkoxyamines exhibiting both stereochemical and positional diversity. Methods for efficient condens
