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782493-57-6

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782493-57-6 Usage

General Description

1-Piperidinecarboxylic acid, 4-(2-amino-2-oxoethyl)-, 1,1-dimethylethyl ester is a chemical compound with the molecular formula C14H26N2O3. It is an ester derived from piperidinecarboxylic acid, aminooxoethyl, and 1,1-dimethylethanol. 1-Piperidinecarboxylic acid, 4-(2-amino-2-oxoethyl)-, 1,1-dimethylethyl ester is commonly used in organic synthesis and pharmaceutical research, and it is known for its ability to act as a substrate or inhibitor for certain enzymes. It may also have potential applications in the development of new drugs and pharmaceuticals due to its structural properties and reactivity. Overall, this compound is of interest to researchers and chemists for its potential uses in various fields of science and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 782493-57-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,2,4,9 and 3 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 782493-57:
(8*7)+(7*8)+(6*2)+(5*4)+(4*9)+(3*3)+(2*5)+(1*7)=206
206 % 10 = 6
So 782493-57-6 is a valid CAS Registry Number.

782493-57-6Relevant articles and documents

Search for potent and selective Aurora A inhibitors based on general Ser/Thr kinase pharmacophore model

Vasilevich, Natalya I.,Tatarskiy, Victor V.,Aksenova, Elena A.,Kazyulkin, Denis N.,Afanasyev, Ilya I.

, (2016/05/02)

Based on the data for compounds known from the literature to be active against various types of Ser/Thr kinases, a general pharmachophore model for these types of kinases was developed. The search for the molecules fitting to this pharmacophore among the ASINEX proprietary library revealed a number of compounds, which were tested and appeared to possess some activity against Ser/Thr kinases such as Aurora A, Aurora B and Haspin. Our work on the optimization of these molecules against Aurora A kinase allowed us to achieve several hits in a 3-5 nM range of activity with rather good selectivity and Absorption, Distribution, Metabolism, and Excretion (ADME) properties, and cytotoxicity against 16 cancer cell lines. Thus, we showed the possibility to fine-tune the general Ser/Thr pharmacophore to design active and selective compounds against desired types of kinases.

NOVEL COMPOUNDS USEFUL AS S100-INHIBITORS

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Page/Page column 68; 69, (2015/12/08)

A compound of formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor of interactions between S100A9 and interaction partners such as RAGE, TLR4 and EMMPRIN and as such is useful in the treatment of disorders such as cancer, autoimmune disorders, inflammatory disorders and neurodegenerative disorders.

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

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Page 90, (2010/02/09)

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula (I): which are used to modulate the CCR-

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