280110-63-6

Usage

Uses

Used in Pharmaceutical Research and Development:
TERT-BUTYL 4-[(Z)-AMINO(HYDROXYIMINO)METHYL]PIPERIDINE-1-CARBOXYLATE is used as a key intermediate in the synthesis of potential drug candidates for various therapeutic applications. Its unique chemical structure allows for the development of new compounds with improved pharmacological properties.
Used in Antiviral Research:
In the field of antiviral research, TERT-BUTYL 4-[(Z)-AMINO(HYDROXYIMINO)METHYL]PIPERIDINE-1-CARBOXYLATE is used as a potential antiviral agent. Its biological activities are being studied to understand its potential role in inhibiting viral replication and preventing the spread of viral infections.
Used in the Treatment of Various Diseases:
TERT-BUTYL 4-[(Z)-AMINO(HYDROXYIMINO)METHYL]PIPERIDINE-1-CARBOXYLATE is also being investigated for its potential therapeutic applications in the treatment of various diseases. Its unique chemical properties make it a valuable molecule for medicinal chemistry studies, with the aim of developing new drugs to address unmet medical needs.
Used in Medicinal Chemistry Studies:
In medicinal chemistry, TERT-BUTYL 4-[(Z)-AMINO(HYDROXYIMINO)METHYL]PIPERIDINE-1-CARBOXYLATE is used as a valuable molecule for understanding the structure-activity relationships of potential drug candidates. Its unique chemical structure and properties provide insights into the design and optimization of new compounds with improved therapeutic efficacy and safety profiles.

Upstream product

• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 157688-46-5 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid 
• 883877-26-7 C₁₇H₂₉NO₆ 
• 782493-57-6 4-carbamoylmethyl-piperidine-1-carboxylic acid tert-butyl ester 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 256411-39-9 tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate 

Downstream Products

• 1238314-13-0 C₁₈H₂₄N₄O₇ 
• 1037793-07-9 4-(5-benzyloxymethyl-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 1471298-12-0 tert-butyl 4-(5-((2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octan-2-yl)-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate 
• 280110-66-9 tert-butyl 4-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate 
• 1037793-05-7 4-[5-(4-methanesulfonylphenoxymethyl)-[1,2,4]oxadiazol-3-yl]piperidine-1-carboxylic acid tert-butyl ester 
• 1433178-90-5 benzyl 4-[5-(1,3-benzothiazol-2-yl)-4-[[(3R)-1-[(tert-butoxy)carbonyl]piperidin-3-yl]amino]-6-oxo-1,6-dihydropyrimidin-2-yl]piperidine-1-carboxylate 
• 1433178-86-9 benzyl 4-[5-(1,3-benzothiazol-2-yl)-4-chloro-6-hydroxypyrimidin-2-yl]piperidine-1-carboxylate 
• 885270-23-5 4-carbamimidoylpiperidine-1-carboxylic acid tertbutyl ester 
• 1082950-23-9 4-carbamimidoyl-piperidine-1-carboxylic acid tert-butyl esteracetic acid salt 
• 1205637-32-6 4-[5-(2,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]piperidine hydrochloride 
• 1205637-01-9 tert-butyl 4-[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]piperidine-1-carboxylate 
• 1054520-94-3 (S)-tert-butyl 4-(5-(1-(2-fluoro-4-(methylsulfonyl)phenyl)pyrrolidin-3-yl)-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate 
• 940868-23-5 tert-butyl 4-(4-{[(4-fluorobenzyl)amino]carbonyl}-5,6-dihydroxypyrimidin-2-yl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy

In this study, a series of novel HDAC inhibitors, using 1,2,4-oxadiazole-containing as the cap group, were synthesized and evaluated in vitro. Compound 14b, N-hydroxy-2-(methyl((3-(1-(4-methylbenzyl)piperidin-4-yl)-1,2,4-oxadiazol-5-yl)methyl)amino)pyrimidine-5-carboxamide, displayed the most potent histone deacetylase (HDAC) inhibition, especially against HDAC1, 2, and 3 with IC50 values of 1.8, 3.6 and 3.0 nM, respectively. In vitro antiproliferative studies confirmed that 14b was more potent than SAHA, with IC50 values against 12 types of cancer cell lines ranging from 9.8 to 44.9 nM. The results of Western blot assays showed that compound 14b can significantly up-regulate the acetylation of the biomarker his-H3 and molecular docking analyses revealed the mode of action of compound 14b against HDAC1. The results of flow-cytometry analysis suggested that compound 14b induces cell cycle arrest at the G1 phase and has apoptotic effects. Further investigation of the activity of 14b on the primary cells of three patients, showed IC50 values of 21.3, 61.1, and 77.4 nM. More importantly, an oral bioavailability of up to 53.52% was observed for 14b. An in vivo pharmacodynamic evaluation demonstrated that compound 14b can significantly inhibit tumor growth in a Daudi Burkitt's lymphoma xenograft model, with tumor inhibition rates of 53.8 and 46.1% observed at 20 and 10 mg/kg when administered p.o. and i.v., respectively. These results indicate that compound 14b may be a suitable lead for further evaluation and development as an HDAC inhibitor and a potent anticancer agent.

AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS

The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the treatment or prevention of various diseases, conditions or disorders.

CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT

PROBLEM TO BE SOLVED: To provide a cyclic amine compound that has insecticidal activity and/or acaricidal activity, has excellent safety, and can be synthesized in an industrially advantageous manner, and a pest control agent containing the same as an active ingredient. SOLUTION: The present invention provides a compound represented by formula (I), or a salt thereof. (Q is halogeno or the like; R1 is cyano or the like; R2 is H, halogeno or the like; R3 is halogeno, C1-6 alkyl or the like; A is O or S; p1 and p2 are 0 or 1; X1 is halogeno, C1-6 alkoxy or the like; m is an integer of 0-4; X2 is H, a halogeno group or the like; Y is C6-10 aryl or the like; X1 and X2 may form oxymethylene oxy groups). SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

CYCLIC AMINE COMPOUND AND PEST CONTROL AGENT

A compound represented by a formula (I), or a salt thereof: wherein Ar1 is a substituted or unsubstituted C6-10 aryl group, or the like; the number of X1 groups that can be substituted on Ar1 is 5 or less; Xsup

Histone deacetylase inhibitor and preparation method and application thereof

The invention provides a compound shown in a formula (A) or a conformational isomer of the compound or an optical isomer of the compound or a pharmaceutically acceptable salt of the compound. Throughan experiment, it is proved that the compound shown in the formula (A) can effectively inhibit the activity of histone deacetylase (HDAC), in addition, the compound, especially the compounds II-1-II-4, the compounds II-6-II-7, the compound II-13, the compound II-15, the compound II-18, the compounds II-25-II-26, the compounds III-1-III-4 and the compounds III-12-III-13, has a significant inhibiting effect on the proliferative activity of multiple kinds of tumor cells, and the inhibiting effect of the compound is superior to that of a known reference compound SAHA. Therefore, the compound has great potential in preparation of histone deacetylase inhibitors and antitumor medicines.

COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES

The present disclosure relates to compounds according to Formula (I), treating diseases.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

OXYMETHYLENE ARYL COMPOUNDS FOR TREATING INFLAMMATORY GASTROINTESTINAL DISEASES OR GASTROINTESTINAL CONDITIONS

Use of oxymethylene aryl GPRl 19 agonists, and optionally DPP IV inhibitors and optionally metformin, for the treatment of inflammatory gastrointestinal diseases or gastrointestinal conditions involving malabsorption of nutrients and/or fluids are provide

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

USP7 is a deubiquitinase implicated in destabilizing the tumor suppressor p53, and for this reason it has gained increasing attention as a potential oncology target for small molecule inhibitors. Herein we describe the biophysical, biochemical, and comput

INDAZOLONES AS MODULATORS OF TNF SIGNALING

The disclosure provides indazolone compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variables are defined herein. The compounds of the disclosure may be useful for treating immunological and oncological conditions.