78265-39-1

Basic information

• Product Name: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-3-methoxy-
• CAS NO: 78265-39-1
• Molecular Formula: C12H17NO3
• Molecular Weight: 223.272
• Mol File: 78265-39-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 393.1±27.0 °C(Predicted)
• Density: 1.111±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-3-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-3-methoxy-(78265-39-1)
• EPA Substance Registry System: Benzamide, N-(2-hydroxy-1,1-dimethylethyl)-3-methoxy-(78265-39-1)

Safety Data

• Hazardous Substances Data: 78265-39-1(Hazardous Substances Data)

Upstream product

• 586-38-9 3-Methoxybenzoic acid 
• 1711-05-3 m-anisoyl chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 27644-78-6 2-(3-methoxy-phenyl)-4,4-dimethyl-oxazolidine 
• 78265-34-6 2-<2-(bromomethyl)-3-methoxyphenyl>-4,4-dimethyl-2-oxazoline 
• 4792-33-0 4-methoxyphthalide 
• 72623-17-7 2-(2-Methyl-3-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 73453-77-7 3-(4,4-dimethyloxazolin 2-yl)anisole 

Relevant articles and documents

Preparation of Polyfunctionalized Aromatic Nitriles from Aryl Oxazolines

A selective ortho,ortho’-functionalization of readily available aryl oxazolines by two successive magnesiations with sBu2Mg in toluene followed by trapping reactions with electrophiles, such as (hetero)aryl iodides or bromides, iodine, tosyl cyanide, ethyl cyanoformate or allylic bromides (39 examples, 62–99 % yield) is reported. Treatment of these aryl oxazolines with excess oxalyl chloride and catalytic amounts of DMF (50 °C, 4 h) provided the corresponding nitriles (36 examples, 73–99 % yield). Conversions of these nitriles to valuable heterocycles are reported, and a tentative mechanism is proposed.

BENZ-FUSED LACTONES I. SYNTHESIS OF 3-METHYL-1(3H)-ISOBENZOFURANONES

Unsubstituted and 3-alkyl substituted 1(3H)-isobenzofuranones are readily prepared in good yields via ortho-metallation of appropriate aromatics.

Chemistry of Aryloxazolines. Applications to the Synthesis of Lignan Lactone Derivatives

The syntheses of several lignan lactone derivatives using aryloxazolines as the pivotal intermediates have been investigated.Metalations on naphthyloxazolines followed by electrophilic addition gave one of the appropriate substituents, whereas methoxy dis