72623-17-7Relevant academic research and scientific papers
Synthesis of anacardic acids by nucleophilic substitution on 2-aryloxazolines
Seijas, Julio A.,Vázquez-Tato, M. Pilar,Martínez, M. Pilar,Santiso, Verónica
, p. 1937 - 1939 (2007/10/03)
A new direct synthesis for anacardic acids based in a nucleophilic substitution of a methoxy group in 2-aryloxazolines by long-chained Grignard reagents is reported.
Carbacyclin analogs
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, (2008/06/13)
Carbacyclin analogs that exhibit platelet aggregation inhibition activity and other biological activites common to structurally related prostacyclins are provided.
Synthesis, Tubulin Binding, Antineoplastic Evalutaion, and Structure-Activity Relationship of Oncodazole Analogues
Kruse, Lawrence I.,Ladd, David L.,Harrsch, Peter B.,McCabe, Francis L.,Mong, Shau-Ming,et al.
, p. 409 - 417 (2007/10/02)
n an attempt to identify a soluble oncodazole analogue that could be easily formulated, a series of substituted oncodazoles was synthesized and evaluated for tubulin binding affinity, in vitro cyctotoxicity against cultured mouse B-16 cells, and ability to prolong lifespan at the maximally tolerated dose in the P388 mouse leukemia model.Biological evaluation of all the isomeric methyloncodazoles demonstrated the thiophene 4'-position to be the only site of significant bulk tolerance, although substitution of this position with polar or charged functional groups abolished biological activity.Simple esters of the 4'-carboxymethyloncodazole were shown to have enhanched antitumor activity and tubulin binding affinity relative to oncodazole.Despite a failure of this study to identify a water-soluble oncodazole with antitumor activity, the structure-activity relationship developed led to a derivative with enhanced activity in the P388 leukemia model and facilitated the preparation of a biologically active photolabile analogue.
ANTHRACYCLINONE SYNTHESES USING STRONG BASE INDUCED CYCLOADDITION OF HOMOPHTHALIC ANHYDRIDES AND RELATED COMPOUNDS
Tamura, Yasumitsu,Sasho, Manabu,Akai, Shuji,Wada, Akimori,Kita, Yasuyuki
, p. 4539 - 4548 (2007/10/02)
The strong base induced cycloaddition of homophthalic anhydrides and related compounds to halo-1,4-naphthoquinone derivatives has been shown to provide short convergent syntheses of anthracyclinones, 4-demethoxydaunomycinone (1), daunomycinone (2), 11-deo
Chemistry of Aryloxazolines. Applications to the Synthesis of Lignan Lactone Derivatives
Meyers, A. I.,Avila, Walter B.
, p. 3881 - 3886 (2007/10/02)
The syntheses of several lignan lactone derivatives using aryloxazolines as the pivotal intermediates have been investigated.Metalations on naphthyloxazolines followed by electrophilic addition gave one of the appropriate substituents, whereas methoxy dis
Studies on the Synthesis of Substituted Phenanthrenoids
Leed, Andrew R.,Boettger, Susan D.,Ganem, Bruce
, p. 1098 - 1106 (2007/10/02)
Highly regioselective reactions for the construction of polysubstituted benzenes 18, 19, 20, 22, 24, and 44-47 are described, including some remarkable site-selective halogenations.These have been employed in the synthesis of halo-, nitro-, amino-, and urethane-substituted stilbenes 37, 38, and 51-56.Ideas for thermal as well as photochemical cyclizations are presented and explored.Stilbene 54 led to the formation of phenanthrenes 57, 58, and 62; likewise 55 furnished two new tricyclics, 60 and 61, whereas irradiation of 52 in tert-butylalcohol captured solvent to produce phenanthrenes 63 and 64.Strategies for the total synthesis of juncusol (1), a cytotoxic phytoalexin, are considered.
SOLVENT AND BASE STUDIES ON THE SITE OF ARYL METALATION OF 2-(3,5-DIMETHOXYPHENYL)-4,4-DIMETHYL-2-OXAZOLINE
Meyers, A. I.,Avila, Walter B.
, p. 3335 - 3338 (2007/10/02)
The position of metalation and alkylation in aryl oxazolines and diethylamides vary drastically when the base (RLi) and solvents are varied.
