78281-71-7

Basic information

• Product Name: 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide
• Synonyms: 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide;Nepafenac IMpurity D
• CAS NO: 78281-71-7
• Molecular Formula: C15H13ClN2O2
• Molecular Weight: 288.72892
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 78281-71-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide(78281-71-7)
• EPA Substance Registry System: 2-AMino-3-benzoyl-5-chlorobenzeneacetaMide(78281-71-7)

Safety Data

• Hazardous Substances Data: 78281-71-7(Hazardous Substances Data)

Usage

Uses

2-Amino-3-benzoyl-5-chlorobenzeneacetamide is an impurity in the synthesis of Nepafenac enac.

Upstream product

• 78281-60-4 2-amino-3-benzoyl-5-chloro-α-(methylthio)phenylacetamide 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 719-59-5 5-chloro-2-aminobenzophenone 

Relevant articles and documents

Development and a practical synthesis of nepafenac intermediate via modified gassman reaction

Modification of nepafenac intermediate synthesis (5A) via Gassman specific ortho-substitution is reported. According to the process, 2-aminobenzophenone (1A) and 2-(methylthio)acetamide (2) were reacted in the convenient temperature conditions, in the presence of N-chlorophthalimide (3) or 1,3-dichloro-5,5- dimethylhydantoin (4), to activate the formation of azasulfonium salt and rearrangement thereof to pure 2-amino-3-benzoyl-α-(methylthio) phenylacetamide (5A). The procedure appears to be suitable for a reaction carried out in a large scale.

Method of producing an inhibitory effect on blood platelet aggregation

Novel 2-amino-3-benzoyl-phenylacetamides are provided having the formula: STR1 wherein R represents hydrogen or lower alkyl, R1 and R2 represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R1 and R2 when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (--NH2), methylamino or dimethylamino, and n is 1 to 3 inclusive. The compounds exhibit anti-inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.