78315-33-0Relevant academic research and scientific papers
Stereoselective synthesis of 1-bromo-(or 1-chloro-) 1,1-difluoro-2-alkenes
Tellier, Frederique,Sauvetre, Raymond
, p. 79 - 82 (1996)
A highly regio- and stereo-selective method for the introduction of a bromo- (or chloro-) difluoromethylene group into various unsaturated systems is described. The key step is the treatment of 1,1-difluoro-1-alken-3-ols with thionyl bromide (or chloride).
Reactivity of 1-bromo-1,1-difluoro-2-alkenes: Synthesis of 1,1 -difluoroolefins
Tellier, Frederique,Duffault, Jean-Marc,Baudry, Monique,Sauvetre, Raymond
, p. 133 - 139 (2007/10/03)
The treatment of 1-bromo-1,1-difluoro-2-alkenes with organometallic reagents in the presence of copper and lithium salts leads to 1,1-difluoroolefins.
Straightforward synthesis of α,β-unsaturated acids and derivatives
Tellier, Frederique,Sauvetre, Raymond
, p. 5433 - 5436 (2007/10/02)
A general C2 vinylic homologation from carbonyl compounds (aldehydes or ketones) which leads to various α,β-insaturated acids, esters and amides, is described.
Stereoselective Syntheses of 3,3-difluoro-1-propene Derivatives
Tellier, Frederique,Sauvetre, Raymond
, p. 7565 - 7566 (2007/10/02)
A highly regio- and stereo-selective introduction of a difluoromethylene group in allylic position is described.The key step is the treatment of 3-acetoxy-1,1-difluoro-1-propenes with Grignard reagents in the presence of copper and lithium salts.
Reaction de CF2=CH2 avec les organolithiens . Une nouvelle preparation du difluorovinyllithium
Sauvetre, R.,Normant, J. F.
, p. 957 - 958 (2007/10/02)
2,2-Difluorovinyllithium has been prepared in quantitative yield from CF2=CH2 and sec.butyllithium at low temperature.Reaction of 2,2-difluorovinyllithium with carbonyl groups gives the corresponding alcohols.
