783325-61-1

Basic information

• Product Name: 4,6-Dimethyl-2-(methylamino)nicotinonitrile
• Synonyms: 4,6-Dimethyl-2-(methylamino)nicotinonitrile
• CAS NO: 783325-61-1
• Molecular Formula: C9H11N3
• Molecular Weight: 161.20374
• Mol File: 783325-61-1.mol

Chemical Properties

• Melting Point: 146-149
• Appearance: /
• CAS DataBase Reference: 4,6-Dimethyl-2-(methylamino)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dimethyl-2-(methylamino)nicotinonitrile(783325-61-1)
• EPA Substance Registry System: 4,6-Dimethyl-2-(methylamino)nicotinonitrile(783325-61-1)

Safety Data

• Hazardous Substances Data: 783325-61-1(Hazardous Substances Data)

Upstream product

• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 
• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 74-89-5 methylamine 
• 60989-51-7 2-imino-4,6-dimethyl-2H-pyran-3-carbonitrile 
• 123-54-6 acetylacetone 
• 109-77-3 malononitrile 
• 90090-75-8 2-(carbamoylmethyl)-4,6-dimethylpyrimidine 
• 32691-58-0 2-(cyanomethylene)-4,6-dimethylpyrimidine 

Relevant articles and documents

Synthesis and antitumor evaluation of some new fused and binary pyridines

Syntheses of some new heterocyclic compounds containing pyridone, thioxopyridine, halogenated-pyridine-carbonitriles, pyrazolopyridine, and pyridine derivatives were achieved. Besides, a modified synthetic method for the synthesis of 2-chloro-4,6-dimethyl-nicotinonitrile () through the reaction of acetylacetone and malononitrile as starting materials was implemented. The reaction of 2-chloronicotinonitrile with substituted amines to 2-aminonicotinonitrile were also investigated. Fused or binary pyridines were tested for cytotoxicity against well-known established model Ehrlich ascites cells in vitro. Compound exhibited a high antitumor activity compared with 5-fluorouracil.

Novel synthesis of some new fluoerescent 2-amino-3-cyanopyridines

Novel synthesis of some new fluorescent 2-amino-3-cyanopyridines 2a-m in the presence of N-hydroxybenzamide or p-toluenesulfonic acid is described. Photophysical data including λAbs. and λFlu. of 2a-m in CH2Cl2,

Investigation of the nucleophilic rearrangement of 2-(cyanomethyl)-1,4,6- trimethylpyrimidinium iodide into 4,6-dimethyl-2-methylaminonicotinic acid nitrile

2-(Cyanomethyl)-1,4,6-trimethylpyrimidinium iodide is rearranged into 4,6-dimethyl-2-methylaminonicotinic acid nitrile by interaction with alcoholic solutions of sodium ethylate, methylamine, and also glycine and β-alanine ethyl esters. This conversion was also observed for the first time for pyrimidinium salts during the process of recording 1H NMR spectra in CD3OD solution containing CD3ONa. After the rearrangement deuterium exchange of the protons of the pyridine ring methyl groups was noted spectrally. It was demonstrated experimentally that for carrying out and completing the recyclization a quantity of nucleophilic reagent must convert the molar equivalent quantity of pyridinium salt.