783371-98-2

Upstream product

• 1419209-06-5 C₁₁H₁₁N₃O₂ 
• 100-52-7 benzaldehyde 
• 853029-98-8 4-oxo-3,4-dihydroquinazoline-2-carbonitrile 
• 28144-70-9 anthranilic acid amide 
• 76617-97-5 4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 29113-33-5 ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate 

Relevant academic research and scientific papers

Synthesis and configurational assignment of 1,2-dihydroimidazo[5,1-b] quinazoline-3,9-diones: Novel NMDA receptor antagonists

NMDA receptors form a major subdivision of the ionotropic glutamate receptor family that mediates excitatory synaptic transmission in the brain. Series of 1-substituted 1,2-dihydroimidazo[5,1-b]quinazolinediones were synthesized and found to have potent nanomolar activity at the glycine site of the NMDA receptor. Imidazoquinazolinediones were prepared by cyclocondensation of 4-oxo-quinazoline-2-carboxamide with aldehydes and orthoesters with good yields. The formed enantiomers were separated by chiral HPLC. The absolute configuration of pure enantiomers is elucidated by combined CD/Quantumchemical time-dependent DFT calculation method (TDDFT).