78338-69-9

Upstream product

• 2315-86-8 3-bromo-4-hydroxybenzonitrile 
• 75-36-5 acetyl chloride 
• 506-96-7 Acetyl bromide 
• 108-24-7 acetic anhydride 

Downstream Products

• 183589-05-1 4-cyano-2-((trimethylsilyl)ethynyl)phenyl acetate 
• 79008-77-8 2-phenylbenzofuran-5-carbonitrile 
• 691857-15-5 4-cyano-2-(phenylethynyl)phenyl acetate 
• 2315-86-8 3-bromo-4-hydroxybenzonitrile 

Relevant academic research and scientific papers

ANTIBACTERIAL AND ANTIFUNGAL PLEUROMUTILIN CONJUGATES

Compounds of formula (1) comprising a pleuromutilin backbone with a triazole based side-group at C22 are provided. The compounds can be used for treatment of bacterial infections and fungal infections. Importantly, infections caused by multidrug-resistant

Efficient synthesis of 5-nitro-benzo[b]furans via 2-bromo-4-nitro-phenyl acetates

Acetylation/Sonogashira cross-coupling reaction/cyclization has been carried out in one-pot using a Na2PdCl4/2-(di-tert-butylphosphino)-N-phenylindole/CuI system in TMEDA to give 5-nitro-2-substituted benzo[b]furans in excellent yields. We also describe the extension of this method to 4-EWG-2-bromo-phenols obtaining 2,5-disubstituted-benzo[b]furans in good yields.