78344-54-4

Upstream product

• 108-86-1 bromobenzene 
• 62-53-3 aniline 
• 121-68-6 dithiobenzoic acid 
• 942-91-6 Carboxymethyl dithiobenzoate 
• 100-52-7 benzaldehyde 
• 15563-40-3 N-thiobenzoylpiperidine 
• 20605-40-7 thiobenzoylhydrazine 
• 91-56-5 indole-2,3-dione 

Relevant academic research and scientific papers

Spiro indolone compound as well as, preparation, method and pharmaceutical composition and application thereof

Spiro indolone compounds, a preparing method, a medicine composition and uses of the compounds are disclosed. In particular, the invention provide spiro indolone compounds shown as a formula I or II, a preparing method of the spiro indolone compounds and

Synthesis and biological evaluation of 5′-phenyl-3′H-spiro- [indoline-3,2′-[1,3,4]oxadiazol]-2-one analogs

A series of 5′-phenyl-3′H-spiro[indoline-3,2′-[1,3,4] thiadiazol]-2-one analogs were synthesized and their Bcl-2 protein inhibitory activities were studied. The lead compound was originally identified using a fluorescence polarization-based competitive binding assay. Among the 10 compounds investigated, 1k showed good binding affinities to Bcl-xL and Mcl-1, with inhibition constants of 8.9 μmol/L and 3.4 μmol/L, respectively. While compound 1c achieved tight binding affinities to Bcl-xL (Ki = 0.16 μmol/L), has the potential to be a new lead compound.

Thiadiazole compounds and methods of use thereof

The present invention relates to Thiadiazole Compounds; compositions comprising an effective dose of a Thiadiazole Compound; and methods treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, cancer, r

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2)

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. Selected compounds 23, 33-35 show sub-micromolar ADAMTS-5 potency and strong SAR trends with selectivity over the related metalloproteases ADAMTS-4 (Aggrecanase-1), MMP12, and MMP13. This series of compounds represents progress toward a selective ADAMTS-5 inhibitor as a disease modifying osteoarthritis drug.

SEMICARBAZONES AND THIOSEMICARBAZONES OF THE HETEROCYCLIC SERIES. XLIV. CYCLIZATION OF ISATIN AND 1-ACETYLISATIN 3-THIOBENZOYLHYDRAZONES

Isatin 3-thiobenzoylhydrazone undergoes cyclization with the addition of the sulfur atom to the C3 atom and closure of the thiadiazole ring.In contrast, 3-thioaroylhydrazones of 1-acetylisatin undergo cyclization with participation of C2 and close the thiadiazine ring with the formation of derivatives of the new heterocyclic system thiadiazinoindole.