78376-13-3

Basic information

• Product Name: 5-[(3,4-Dimethoxy-phenyl)-hydroxy-methyl]-4-methoxy-5H-furan-2-one
• Synonyms: 5-[(3,4-Dimethoxy-phenyl)-hydroxy-methyl]-4-methoxy-5H-furan-2-one
• CAS NO: 78376-13-3
• Molecular Weight: 280.277
• Mol File: 78376-13-3.mol

Chemical Properties

• CAS DataBase Reference: 5-[(3,4-Dimethoxy-phenyl)-hydroxy-methyl]-4-methoxy-5H-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(3,4-Dimethoxy-phenyl)-hydroxy-methyl]-4-methoxy-5H-furan-2-one(78376-13-3)
• EPA Substance Registry System: 5-[(3,4-Dimethoxy-phenyl)-hydroxy-methyl]-4-methoxy-5H-furan-2-one(78376-13-3)

Safety Data

• Hazardous Substances Data: 78376-13-3(Hazardous Substances Data)

Upstream product

• 86268-15-7 methyl 5-lithiotetronate 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1116-51-4 ethyl χ-bromo-β-methoxycrotonate 
• 3510-99-4 3-methoxy-but-2-enoic acid ethyl ester 
• 69556-70-3 4-methoxy-5H-furan-2-one 

Downstream Products

• 111671-04-6 5-[1-(3,4-Dimethoxy-phenyl)-meth-(Z)-ylidene]-4-methoxy-5H-furan-2-one 
• 1448595-32-1 (Z)-3-bromo-5-(3,4-dimethoxybenzylidene)-4-methoxyfuran-2(5H)-one 

Relevant articles and documents

A Rapid Entry to Diverse γ-Ylidenetetronate Derivatives through Regioselective Bromination of Tetronic Acid Derived γ-Lactones and Metal-Catalyzed Postfunctionalization

The synthesis of a series of diverse methyl and benzyl γ-ylidenetetronate derivatives was accomplished through the condensation of methyl and benzyl tetronates with (hetero)aryl aldehydes in a new two- or three-step aldolisation/dehydration sequence. The bromination of methyl and benzyl γ-ylidenetetronates occurred under mild conditions to provide the corresponding C-3-brominated γ-unsaturated lactones. Di- and tribrominated γ-lactones were prepared under slightly different conditions. Some brominated materials were employed in representative Stille, Suzuki-Miyaura, and Sonogashira cross-coupling reactions to yield functionalized methyl and benzyl γ-ylidenetetronate derivatives. Compounds that resulted from the Sonogashira cross-coupling reactions were desilylated and converted into 1,2,3-triazole derivatives through a copper(I)-catalyzed 1,3-dipolar cycloaddition reaction with benzyl azide.

Regioselective bromination of tetronic acid-derived γ-lactones and metal-catalyzed post-functionalization: An efficient access to new γ-ylidenetetronate derivatives

The synthesis of several methyl and benzyl γ-ylidenetetronates was accomplished and the bromination reactions of these derivatives, using bromine or N-bromosuccinimide (NBS), were found to occur under mild conditions. Several new brominated γ-unsaturated

Synthetic Routs to the Piperolides, Faydenolides, Epoxypiperolides, and Related Compounds

Syntheses of the piperolides, the faydenolides, epoxypiperolide, and related compounds are described. (+/-)-Narthogenin is also efficiently produced.