784-50-9

Usage

Uses

Used in Organic Synthesis:
9-Fluorenone-2-carboxylic acid is used as a synthetic building block for the creation of more complex organic molecules. Its unique structure allows it to be a versatile component in the synthesis of various compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 9-Fluorenone-2-carboxylic acid is used as an intermediate in the development of new drugs. Its chemical properties make it a suitable candidate for the synthesis of novel therapeutic agents, potentially contributing to the advancement of treatments for various diseases and conditions.
Used in Chemical Research:
9-Fluorenone-2-carboxylic acid is also utilized in chemical research as a model compound for studying the properties and reactivity of fluorenone derivatives. This helps researchers understand the behavior of similar compounds and develop new strategies for their synthesis and application.
Used in Material Science:
9-Fluorenone-2-carboxylic acid may also find applications in material science, particularly in the development of new polymers and other advanced materials. Its unique chemical structure could contribute to the creation of materials with specific properties, such as improved stability, reactivity, or functionality.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 3958, 1948 DOI: 10.1021/ja01191a530Organic Syntheses, Coll. Vol. 3, p. 420, 1955

InChI:InChI=1/C14H8O3/c15-13-11-4-2-1-3-9(11)10-6-5-8(14(16)17)7-12(10)13/h1-7H,(H,16,17)/p-1

Upstream product

• 781-73-7 1-(9H-fluoren-2-yl)ethanone 
• 7507-40-6 9H-fluorene-2-carboxylic acid 
• 42136-05-0 2-acetylfluoren-9-one 
• 606-80-4 (1,1'-biphenyl)-2,4'-dicarboxylic acid 
• 4445-50-5 biphenyl-2,4'-dicarboxylic acid 
• 92429-66-8 9-oxo-fluorene-1,2-dicarboxylic acid 
• 20371-86-2 1-(9H-fluoren-2-yl)ethan-1-ol 
• 65814-23-5 2-(4-amino-3,5-dimethylphenyl)fluorenone 
• 58473-49-7 3,3-Bis-(9H-fluoren-2-yl)-butan-2-one 
• 86476-54-2 2-carboxyfluoren-9-ol 
• 41085-71-6 bromamine T 
• 4433-10-7 2,4-dimethyl-1,1'-biphenyl 
• 64-19-7 acetic acid 
• 1430-97-3 2-methyl-9H-fluorene 

Downstream Products

• 39180-42-2 2-(9-oxofluorenyl)carbonyl chloride 
• 877667-26-0 3-(3-(trifluoromethyl)diazirin-3-yl)phenyl-9-oxo-9H-fluorene-2-carboxylate 
• 119034-65-0 1-(9-oxo-2-fluorenylcarbonyl)-4-(3,4,5-trimethoxybenzyl)piperazine 
• 876762-47-9 C₂₁H₂₁NO₂ 
• 1372415-93-4 C₂₅H₂₄O₆S 
• 1430-97-3 2-methyl-9H-fluorene 

Relevant academic research and scientific papers

A new technique to prepare 9-oxofluorene-2-carboxylic acid

9-Oxofluorene-2-carboxylic acid has been obtained with a yield as high as 98.5%, following a new procedure with easy product extraction, based on the reaction of 2-acetylfluorene with sodium dichromate in acetic acid.

Method for synthesizing fluorenone ketone compound through molecular oxygen oxidation in water phase

Aiming at the technical problems that in the prior art a method for synthesizing a fluorenone ketone compound has organic solvent pollution and byproducts can be generated, the invention provides a method for synthesizing a fluorenone ketone compound through molecular oxygen oxidation in a water phase. The method comprises the following steps: by taking a fluorenone compound as a substrate, dispersing into an alkali solution, and at 40-120 DEG C, in the presence of oxygen, and with a water-soluble transition metal compound as a catalyst, stirring to carry out reactions, thereby obtaining the fluorenone ketone compound. By adopting the method, molecular oxygen is adopted as an oxidant, and water is adopted as a solvent, so that an organic solvent is avoided, and the problem that multiple byproducts are generated because of peroxidation can be avoided.

With Wnt signal path to inhibit the active heterocyclic compounds (by machine translation)

The invention relates to a signal path with Wnt inhibiting activity of a heterocyclic compound, including the compound and its pharmaceutically acceptable salt, various isotope, various isomers or various crystal structure, having the general formula I of the structure shown in: the invention relates to a compound and its joint application composition can effectively inhibit the Wnt signal path, can be used for the treatment or prevention of a disorder associated with a Wnt signal path. (by machine translation)

Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the ‘reversed’ amide scaffold

The Wnt signaling pathway is an essential signal transduction pathway which leads to the regulation of cellular processes such as proliferation, differentiation and migration. Aberrant Wnt signaling is known to have an association with multiple cancers. Porcupine is an enzyme that catalyses the addition of palmitoleate to a serine residue in Wnt proteins, a process which is required for the secretion of Wnt proteins. Here we report the synthesis and structure–activity-relationship of the novel porcupine inhibitors based on a ‘reversed’ amide scaffold. The leading compound 53 was as potent as the clinical compound LGK974 in a cell based STF reporter gene assay. Compound 53 potently inhibited the secretion of Wnt3A, therefore was confirmed to be a porcupine inhibitor. Furthermore, compound 53 showed excellent chemical and plasma stabilities. However, the clearance of compound 53 in liver microsomal tests was moderate to high, and the solubility of compound 53 was suboptimal. Collective efforts toward further optimization of this novel tricyclic template to develop better porcupine inhibitors will be subsequently undertaken and reported in due course.

Polymeric Reagents Comprising a Terminal Vinylic Group and Conjugates Formed Therefrom

The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

Optimized liquid-phase oxidation

Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly effic

Optimized liquid-phase oxidation

Disclosed is an optimized process and apparatus for more efficiently and economically carrying out the liquid-phase oxidation of an oxidizable compound. Such liquid-phase oxidation is carried out in a bubble column reactor that provides for a highly effic

Antithrombotic agents

This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.

Liquid-Phase Catalytic Oxidation of 2,4-Dimethylbiphenyl

2,4-Dimethylbiphenyl synthesized by alkylalion of m-xylene with cyclohexanol and subsequent dehydrogenation was oxidized catalytically in the liquid phase to 2,4-biphenyldicarboxylic acid. The effects of temperature, the catalyst, and initial concentrations of reactants on the rate and efficiency of the process were studied.

TRINITRO-9-OXOFLUORENECARBOXAMIDES AS CHIRAL ELECTRON ACCEPTORS

Trinitrofluorenecarboxamides, labeled with optically active α-phenylethylamine and some of its derivatives, were synthesized in a continuation of researches into new chiral electron acceptors of the nitrofluorene series.Their possible use as chiral acceptors in the resolution of compounds into enantiomers by chromatographic separation of diastereomeric charge-transfer complexes was investigated.