784149-92-4Relevant academic research and scientific papers
Pyridine-3-propanoic acids: Discovery of dual PPARα/γ agonists as antidiabetic agents
Humphries, Paul S.,Bailey, Simon,Almaden, Jonathon V.,Barnum, Sandra J.,Carlson, Thomas J.,Christie, Lance C.,Do, Quyen-Quyen T.,Fraser, James D.,Hess, Mary,Kellum, Jack,Kim, Young H.,McClellan, Guy A.,Ogilvie, Kathleen M.,Simmons, Brett H.,Skalitzky, Donald,Sun, Shaoxian,Wilhite, David,Zehnder, Luke R.
, p. 6120 - 6123 (2007/10/03)
A series of novel pyridine-3-propanoic acids was synthesized. A structure-activity relationship study of these compounds led to the identification of potent dual PPARα/γ agonists with varied isoform selectivity. Based on the results of efficacy studies in
