78416-88-3

Basic information

• Product Name: 5,6-dimethoxyindeno[1,2,3-ij]isoquinolin-9(1H)-one
• CAS NO: 78416-88-3
• Molecular Formula: C₁₇H₁₃NO₃
• Molecular Weight: 279.29
• Mol File: 78416-88-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 736.5°C at 760 mmHg
• Flash Point: 399.3°C
• Density: 1.37g/cm³
• Vapor Pressure: 1.47E-21mmHg at 25°C
• Refractive Index: 1.689
• CAS DataBase Reference: 5,6-dimethoxyindeno[1,2,3-ij]isoquinolin-9(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-dimethoxyindeno[1,2,3-ij]isoquinolin-9(1H)-one(78416-88-3)
• EPA Substance Registry System: 5,6-dimethoxyindeno[1,2,3-ij]isoquinolin-9(1H)-one(78416-88-3)

Safety Data

• Hazardous Substances Data: 78416-88-3(Hazardous Substances Data)

Upstream product

• 6948-30-7 5-bromoveratralaldehyde 
• 162147-12-8 2-Bromo-5-isopropoxybenzaldehyde 
• 75792-33-5 3-isopropoxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 2973-76-4 5-bromo-4-hydroxy-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 56139-04-9 2-(3-bromo-4,5-dimethoxyphenyl)ethanamine 
• 54291-90-6 5-bromo-3,4-dimethoxy-1-(2-nitrovinyl)benzene 

Relevant articles and documents

Divergent Total Syntheses to Azafluoranthene and Dehydroaporphine Alkaloids

Facile divergent total syntheses for azafluoranthene and dehydroaporphine alkaloids have been successfully developed. A common intermediate, a biarylsulfonamide-protected amino aldehyde, underwent either a cascade or a stepwise cyclization to furnish a tetracyclic skeleton related to the azafluoranthene alkaloids. Natural products, triclisine and telitoxine, were prepared to illustrate the use of this approach. Subsequent C-homologation of the aldehyde moiety on the same intermediate by means of a Wittig reaction allowed the synthesis of aporphine alkaloids, as exemplified by the preparation of dehydronornuciferine. This synthetic approach could be applicable to the syntheses of other azafluoranthene-related as well as aporphine-related alkaloids. Facile divergent syntheses for azafluoranthene and dehydroaporphine alkaloids are reported by using a biarylsulfonamide-protected amino aldehyde as a common intermediate. The natural azafluoranthenes, triclisine and telitoxine, and an aporphine alkaloid, dehydronornuciferine, were prepared to illustrate the use of this approach.