784161-48-4 Usage
Uses
1. Used in Chemical Synthesis:
1-Boc-2-indolyldimethylsilanol, 95% is used as a silicon nucleophile for palladium-catalyzed cross-coupling reactions. This application is significant because it allows for the formation of new carbon-carbon and carbon-heteroatom bonds, which are essential in the synthesis of complex organic molecules.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Boc-2-indolyldimethylsilanol, 95% is used as a reactant for palladium-catalyzed cross-coupling reactions. These reactions are crucial in the development of new drugs and the modification of existing ones, as they enable the creation of diverse molecular structures with potential therapeutic properties.
3. Used in Material Science:
1-Boc-2-indolyldimethylsilanol, 95% can also be utilized in the field of material science, where palladium-catalyzed cross-coupling reactions are employed to synthesize novel materials with unique properties. These materials can be used in various applications, such as electronics, energy storage, and advanced coatings.
4. Used in Research and Development:
In research and development, 1-Boc-2-indolyldimethylsilanol, 95% serves as an essential tool for chemists to explore new reaction pathways and develop innovative synthetic methods. Its use in palladium-catalyzed cross-coupling reactions can lead to the discovery of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 784161-48-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,8,4,1,6 and 1 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 784161-48:
(8*7)+(7*8)+(6*4)+(5*1)+(4*6)+(3*1)+(2*4)+(1*8)=184
184 % 10 = 4
So 784161-48-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H21NO3Si/c1-15(2,3)19-14(17)16-12-9-7-6-8-11(12)10-13(16)20(4,5)18/h6-10,18H,1-5H3
784161-48-4Relevant academic research and scientific papers
Palladium-catalyzed cross-coupling of five-membered heterocyclic silanolates
Denmark, Scott E.,Baird, John D.,Regens, Christopher S.
, p. 1440 - 1455 (2008/04/12)
(Chemical Equation Presented) The preparation of π-rich 2-aryl heterocycles by palladium-catalyzed cross-coupling of sodium heteroarylsilanolates with aryl iodides, bromides, and chlorides is described. The cross-coupling process was developed through extensive optimization of the following key variables: (1) identification of stable, isolable alkali metal silanolates, (2) identification of conditions for preformation and isolation of silanolate salts, (3) judicious choice in the palladium catalyst/ligand combination, and (4) selection of the protecting group on the nitrogen of indole. It was found that the alkali metal silanolates, either isolated or formed in situ, offered a significant rate enhancement and broader substrate scope over the use of silanols activated by Bronsted bases such as NaOt-Bu. In addition, the optimized conditions for the cross-coupling of 2-indolylsilanolates were readily applied to the cross-coupling of 2-pyrrolyl-, 2-furyl-, and 2-thienylsilanolates.
Palladium-catalyzed cross-coupling reactions of 2-indolyldimethylsilanols with substituted aryl halides
Denmark, Scott E.,Baird, John D.
, p. 3649 - 3652 (2007/10/03)
(Chemical Equation Presented) A mild and general cross-coupling reaction of 2-indolylsilanols has been developed. The experimental variables that lead to successful coupling are (1) the use of sodium terf-butoxide as the activator, (2) the use of copper(l) iodide in stoichiometric quantities, and (3) the use of Pd2-(dba)3·CHCl3 as the catalyst. Under these conditions N-(Boc)-2-indolyldimethylsilanol reacts with a variety of aromatic iodides to afford the coupling products in good yield (70-84%).
