78433-22-4Relevant academic research and scientific papers
Chemical transformations on botryane skeleton. Effect on the cytotoxic activity
Reino, Jose L.,Duran-Patron, Rosa,Segura, Inmaculada,Hernandez-Galan, Rosario,Riese, Hans H.,Collado, Isidro G.
, p. 344 - 349 (2007/10/03)
Eighteen compounds with a botryane skeleton have been obtained through chemical transformations of various toxins from the fungus Botrytis cinerea. During the course of these transformations, the C-10 carbon of the botryane skeleton was found to exhibit an interesting high regioselectivity to oxidizing and reducing agents. In addition, the cytotoxicity of 27 botryane derivatives was determined in vitro against Hs578T, MDA-MB-231, HT-1080, U87-MG, IMR-90, and HUVEC cell lines. The results of this study confirm that the cytotoxicity of botrydial (1) and its derivatives is related to the presence of a 1,5-dialdehyde functionality.
Studies in Terpenoid Biosynthesis. Part 25. The Fate of the Mevalonoid Hydrogen Atoms in the Biosynthesis of the Sesquiterpenoid, Dihydrobotrydial
Bradshaw, A. Peter W.,Hanson, James R.,Nyfeler, Robert,Sadler, Ian H.
, p. 2187 - 2192 (2007/10/02)
The 1H n.m.r. spectrum of dihydrobotrydial and its ethyl ether were assigned.The number of mevalonoid lebels that were incorporated into dihydrobotrydial by the fungus, Bortrytis cinerea, were determined from 3H:14C ratio studies whilst the location of the labels was defined by 2H n.m.r. methods.A 1,3-hydrogen shift occurs during the cyclization and 18O studies show that the 9-hydroxy-group arises from water.
