78435-31-1Relevant academic research and scientific papers
Selective hydroboration of equilibrating allylic azides
Liu, Ruzhang,Zhang, Yuanyuan,Xu, Jun
, p. 8913 - 8916 (2021/09/13)
The iridium(i)-catalyzed hydroboration of equilibrating allylic azides is reported to provide only the anti-Markovnikov product of alk-1-ene isomers in good yields and with good functional group tolerance.
A mitochondria-targeted mass spectrometry probe to detect glyoxals: Implications for diabetes
Pun, Pamela Boon Li,Logan, Angela,Darley-Usmar, Victor,Chacko, Balu,Johnson, Michelle S.,Huang, Guang W.,Rogatti, Sebastian,Prime, Tracy A.,Methner, Carmen,Krieg, Thomas,Fearnley, Ian M.,Larsen, Lesley,Larsen, David S.,Menger, Katja E.,Collins, Yvonne,James, Andrew M.,Kumar, G.D. Kishore,Hartley, Richard C.,Smith, Robin A.J.,Murphy, Michael P.
supporting information, p. 437 - 450 (2015/02/19)
The glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia disrupts cell function and contributes to many pathologies, including those associated with diabetes and aging. Intracellular glycation occurs after the generation of the reactive 1,2-dicarbonyls methylglyoxal and glyoxal, and disruption of mitochondrial function is associated with hyperglycemia. However, the contribution of these reactive dicarbonyls to mitochondrial damage in pathology is unclear owing to uncertainties about their levels within mitochondria in cells and in vivo. To address this we have developed a mitochondria-targeted reagent (MitoG) designed to assess the levels of mitochondrial dicarbonyls within cells. MitoG comprises a lipophilic triphenylphosphonium cationic function, which directs the molecules to mitochondria within cells, and an o-phenylenediamine moiety that reacts with dicarbonyls to give distinctive and stable products. The extent of accumulation of these diagnostic heterocyclic products can be readily and sensitively quantified by liquid chromatography-tandem mass spectrometry, enabling changes to be determined. Using the MitoG-based analysis we assessed the formation of methylglyoxal and glyoxal in response to hyperglycemia in cells in culture and in the Akita mouse model of diabetes in vivo. These findings indicated that the levels of methylglyoxal and glyoxal within mitochondria increase during hyperglycemia both in cells and in vivo, suggesting that they can contribute to the pathological mitochondrial dysfunction that occurs in diabetes and aging.
A new strategy for synthesis of polymeric supports with triazene linkers
Lazny, Ryszard,Nodzewska, Aneta,Klosowski, Piotr
, p. 121 - 130 (2007/10/03)
A new strategy based on the use of diethylamine triazenes for stabilization and generation of polymer supported diazonium ions was described. New economical syntheses of four new polymeric supports with 3- and 6-carbon atom spacers and triazene linkers derived from meta- and para-aminophenol were described and compared to the traditional methods. The possible application of the polymer bound triazene masked diazonium salts as supports for immobilization of secondary amines (nortropine and 4-piperidinole and their esterification and oxidation), and as amine scavengers was shown. The new supports with meta-C3-T2 and para-C3-T2 linkers showed higher loadings and typically gave products with good yields and purities.
