78443-35-3

Basic information

• Product Name: 3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile
• Synonyms: 3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile
• CAS NO: 78443-35-3
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.26
• Mol File: 78443-35-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 116-118°
• Boiling Point: 418.129 °C at 760 mmHg
• Flash Point: 206.677 °C
• Appearance: /
• Density: 1.128 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• CAS DataBase Reference: 3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile(78443-35-3)
• EPA Substance Registry System: 3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile(78443-35-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 78443-35-3(Hazardous Substances Data)

Usage

General Description

3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile is a chemical compound that belongs to the family of biphenyl compounds. It is a nitrile derivative, characterized by a nitrile group attached to a 3-oxopropane moiety. 3-[1,1'-biphenyl]-4-yl-3-oxopropanenitrile has potential applications in the fields of organic synthesis and medicinal chemistry, due to its unique structure and reactivity. Its ability to undergo various chemical reactions makes it a versatile building block for the synthesis of more complex organic molecules. Additionally, its biphenyl core imparts unique properties that can be exploited for the development of novel materials and pharmaceuticals. However, the compound's specific uses and properties would depend on its chemical and physical characteristics, as well as its interactions with other substances.

InChI:InChI=1/C15H11NO/c16-11-10-15(17)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10H2

Upstream product

• 635-84-7 4-(chloroacetyl)biphenyl 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 84864-17-5 5-(<1,1'-biphenyl>-4-yl)-isoxazole 
• 135-73-9 2-Bromo-4'-phenylacetophenone 
• 1116-98-9 cyanoacetic acid tert-butyl ester 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 82102-37-2 9-methyl-9H-fluorene-9-carbonyl chloride 
• 773837-37-9 sodium cyanide 
• 84864-25-5 3-(<1,1'-biphenyl>-4-yl)-3-oxopropionaldehyde oxime 
• 71804-44-9 2-isocyanoacetic acid 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 60131-48-8 (E)-3-Biphenyl-4-yl-3-chloro-acrylonitrile 
• 5122-94-1 4-biphenylboronic acid 

Downstream Products

• 88876-75-9 (Z)-2-(Biphenyl-4-carbonyl)-3-(4-chloro-phenyl)-acrylonitrile 
• 90284-22-3 (Z)-2-(Biphenyl-4-carbonyl)-3-(4-hydroxy-phenyl)-acrylonitrile 
• 90284-21-2 (Z)-2-(Biphenyl-4-carbonyl)-3-(4-iodo-phenyl)-acrylonitrile 
• 90284-18-7 (Z)-2-(Biphenyl-4-carbonyl)-3-(4-isopropyl-phenyl)-acrylonitrile 
• 1401051-14-6 2,3,5,7,8-pentaphenylnaphtho[1,8-bc]pyran-9-carbonitrile 
• 84864-05-1 3-(Biphenyl-4-carbonyl)-4-hydroxy-pyrrole-2,5-dione 
• 223423-52-7 2-amino-3-(4-phenylbenzoyl)-4,5,6,7-tetrahydrothieno(2,3-c)pyridine 
• 223423-49-2 2-amino-3-(4-phenylbenzoyl)-6-(benzyloxycarbonyl)-4,5,6,7-tetrahydrothieno(2,3-c)pyridine 

Relevant articles and documents

Deadly KCN and pricey metal free track for accessing β-ketonitriles employing mild reaction conditions

A one pot synthesis of β-ketonitriles from readily accessible 3-chloropropenals using economically benign iodine, aqueous ammonia and sodium hydroxide solution, employing mild reaction conditions have been described. This report presents a convenient, inexpensive, highly toxic-matter-free and eco-friendly approach for β-ketonitriles.

Method for synthesizing beta-ketonitrile and derivatives thereof

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Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center

A new transformation pattern for enantioselective intramolecular hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals were converted to C3- or C3,C5-chirogenic cyclopentanones with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theoretically calculated and the origin of the stereoselection is rationally explained.