78444-54-9Relevant articles and documents
6-substituted-4-hydroxytetrahydropyran-2-one derivatives and pharmaceutical compositions containing them
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, (2008/06/13)
The present invention provides compounds of the general formula: STR1 wherein E is an alkylene or alkenylene radical containing 2 carbon atoms, R1 is a cycloaliphatic hydrocarbon radical containing 5 to 12 carbon atoms, which is optionally subs
Substituted pyranone inhibitors of cholesterol synthesis
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, (2008/06/13)
The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.
SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS
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, (2008/06/13)
6-Phenyl-, phenylalkyl-and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductas