78444-54-9

Upstream product

• 78444-53-8 N-(2-hydroxy-1,1-dimethylethyl)-2,4-dichloro-6-methoxybenzamide 
• 99725-35-6 2,4-dichloro-6-methoxybenzoic acid chloride 
• 78444-52-7 2,4-dichloro-6-methoxybenzaldehyde 
• 78443-72-8 4,6-dichlorosalicylaldehyde 

Downstream Products

• 99725-38-9 2-<2,4-dichloro-6-(2-phenylethyl)phenyl>-4,5-dihydro-4,4-dimethyloxazole 
• 352-13-6 4-flourophenylmagnesium bromide 

Relevant academic research and scientific papers

6-substituted-4-hydroxytetrahydropyran-2-one derivatives and pharmaceutical compositions containing them

The present invention provides compounds of the general formula: STR1 wherein E is an alkylene or alkenylene radical containing 2 carbon atoms, R1 is a cycloaliphatic hydrocarbon radical containing 5 to 12 carbon atoms, which is optionally subs

3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 3. 7-(3,5-Disubstituted -2-yl)-3,5-dihydroxy-6-heptenoic Acids and Their Lactone Derivatives

The syntheses of a series of 7-(3,5-disubstituted -2-yl)-3,5-dihydroxy-6-heptenoic acids and their lactones are reported.Intrinsic 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitory activity is enhanced markedly when the biphenyl mo

Substituted pyranone inhibitors of cholesterol synthesis

The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

Substituted pyranone inhibitors of cholesterol synthesis

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS

6-Phenyl-, phenylalkyl-and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductas

Cis/trans isomerization of 6-(substituted-aryl-ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones

Biologically inactive cis-6-(substituted-arylethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-ones are isomerized to the corresponding anti-hypercholesterolemic trans-isomers by heating in the presence of a heavy metal salt.