78469-85-9Relevant articles and documents
Chemoenzymatic Synthesis of Homoazasugars
Henderson, Ian,Laslo, Karen,Wong, Chi-Huey
, p. 359 - 362 (1994)
A chemoenzymatic approach for the synthesis of homoazasugars is described, utilizing an aldolase to catalyse the key asymmetric aldol addition reaction.This approach is illustrated by the synthesis of β-D-homomannonojirimycin (11) using D-fructose diphosp
Heterogeneous asymmetric epoxidation of cis-allylic alcohols: Use of polymer-supported Ti(IV)-catalyst
Karjalainen, Jaana K.,Hormi, Osmo E. O.,Sherrington, David C.
, p. 2019 - 2022 (1998)
Heterogeneous asymmetric epoxidation of cis-allylic alcohols with titanium isopropoxide and tert-butyl hydroperoxide has been achieved using a branched/crosslinked poly(tartrate ester) ligand. The enantioselectivities and chemical yields obtained are at l
Formal synthesis of borrelidin: A highly enantio- and diastereoselective access to the Morken's C2-C12 intermediate
Gembus, Vincent,Karmazin, Lydia,Uguen, Daniel,Zoller, Thomas
supporting information, p. 359 - 380 (2019/02/25)
In contrast to methyl and isobutyl phenyl sulfone, condensing under basic conditions higher alkyl sulfones and trans-2,3-epoxy-butanol 13c (or its O-benzyl and O-silyl derivatives) proved unfeasible, a difficulty that was overcome by using mono ethers of trans-2,3-epoxy-butane-1,4-diol 35c as the electrophilic reagents. Thus, adding excess BuLi to a mixture of the benzyl ether 35b and sulfone ent-12a, a stereodiad sulfone prepared in pure state from the R-Roche ester, via the O-trityloxy-sulfone ent-12c (X-ray), gave, after elimination by column chromatography of the side-formed regioisomer, a diolsulfone that was next converted to sulfone 20 by means of conventional functional-group modifications. Reacting like-wise this sulfone with the parent O-PMB derivative 35a, and then proceeding to the same purification process and function adjustment, delivered the title fragment in virtually pure state.
HIV PROTEASE INHIBITORS
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Page/Page column 37, (2015/07/07)
The present invention is directed to 2,5,6-substituted morpholine derivatives and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis,