78531-65-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(1',1''-BIPHENYL-4'-YL)-CYCLOHEXANONE is used as a building block for the synthesis of various organic compounds and pharmaceuticals, serving as a starting material for the preparation of novel drugs and biologically active molecules.
Used in Medicinal Chemistry:
4-(1',1''-BIPHENYL-4'-YL)-CYCLOHEXANONE is used as a starting material for the development of new drugs and biologically active molecules, contributing to the advancement of medicinal chemistry.
Used in Biological Activity Research:
4-(1',1''-BIPHENYL-4'-YL)-CYCLOHEXANONE is used in the study of its potential biological activities, such as anti-inflammatory and antioxidant properties, which may lead to its application in the development of therapeutic agents.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 1345511-16-1 2,5-dihydro-[1,1':4',1″-terphenyl]-4(3H)-one 
• 78531-62-1 8-([1,1'-biphenyl]-4-yl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 78531-63-2 8-Biphenyl-4-yl-1,4-dioxa-spiro[4.5]dec-7-ene 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 78531-64-3 8-Biphenyl-4-yl-1,4-dioxa-spiro[4.5]decane 

Downstream Products

• 1402080-54-9 5-([1,1'-biphenyl]-4-yl)oxepan-2-one 
• 134153-36-9 [4-(4-Biphenyl-4-yl-cyclohexyl)-phenyl]-phenyl-methanone 
• 134153-36-9 [4-(4-Biphenyl-4-yl-cyclohexyl)-phenyl]-phenyl-methanone 
• 134153-37-0 1-[4-(4-Biphenyl-4-yl-cyclohexyl)-phenyl]-ethanone 
• 134153-37-0 1-[4-(4-Biphenyl-4-yl-cyclohexyl)-phenyl]-ethanone 

Relevant academic research and scientific papers

NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES

Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.

Enantioselective baeyer-villiger oxidation: Desymmetrization of meso cyclic ketones and kinetic resolution of racemic 2-arylcyclohexanones

Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso cyclic ketones were achieved in the presence of chiral N,N'-dioxide-Sc III complex catalysts. The BV oxidations of prochiral cyclohexanones and cyclobutanones afforded series of optically active μ- and γ-lactones, respectively, in up to 99% yield and 95% ee. Meanwhile, the kinetic resolution of racemic 2-arylcyclohexanones was also realized via an abnormal BV oxidation. Enantioenriched 3-aryloxepan-2-ones, whose formation is counter to the migratory aptitude, were obtained preferentially. Both the lactones and the unreacted ketones were obtained with high ee values.

Enantioselective baeyer-villiger oxidation: Desymmetrization of meso cyclic ketones and kinetic resolution of racemic 2-arylcyclohexanones

Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso cyclic ketones were achieved in the presence of chiral N,N'-dioxide-Sc III complex catalysts. The BV oxidations of prochiral cyclohexanones and cyclobutanones afforded series of optically active μ- and γ-lactones, respectively, in up to 99% yield and 95% ee. Meanwhile, the kinetic resolution of racemic 2-arylcyclohexanones was also realized via an abnormal BV oxidation. Enantioenriched 3-aryloxepan-2-ones, whose formation is counter to the migratory aptitude, were obtained preferentially. Both the lactones and the unreacted ketones were obtained with high ee values.

Bronsted acid-catalyzed enantioselective Friedlaender condensations: Achiral amine promoter plays crucial role in the stereocontrol

A highly enantioselective Friedlaender condensation has been established by using chiral Bronsted acids in combination with achiral amines to give quinolines in high yields (up to 99%) and with excellent enantioselectivities (up to 95%).

Free Energy and Structure Dependence of Intramolecular Triplet Energy Transfer in Organic Model Compounds

A series of compounds, each containing a triplet energy donor and an acceptor separated by a rigid spacer, has been designed and synthesized.The 1,4-cyclohexanediyl moiety is employed as the spacer for the series.The rates of intramolecular triplet energy