78533-10-5

Upstream product

• 64-17-5 ethanol 
• 108994-19-0 4-p-anisidino-4-methyl-5-oxo-4,5-dihydro-furan-2-carboxylic acid 
• 109247-53-2 2,4-di-p-anisidino-4-methyl-5-oxo-tetrahydro-furan-2-carboxylic acid 
• 141-78-6 ethyl acetate 
• 104-94-9 4-methoxy-aniline 
• 75-07-0 acetaldehyde 
• 127-17-3 2-oxo-propionic acid 
• 5470-34-8 4-methoxyformanilide 
• 67-64-1 acetone 
• 110-86-1 pyridine 

Downstream Products

• 50741-53-2 6-hydroxy-2-methyl-quinoline-4-carboxylic acid 
• 1045559-18-9 N-(1-benzylpiperidin-4-yl)-6-methoxy-2-methylquinoline-4-carboxamide 

Relevant academic research and scientific papers

Synthesis of novel 2-methyl-4-carboxyquinolines, the new by-products of the Doebner reaction

The Doebner reaction is the chemical reaction of an aniline with an aldehyde and pyruvic acid to form quinoline-4-carboxylic acids. Although Doebner reaction is a simple procedure for synthesis of 4-carboxyquinolines, which the product precipitates from the reaction mixtures with high purity, its yield is not high due to the formation of different reaction by-products. In the present study we found a new by-product (2-methylquinoline-4-carboxilic acid derivative), in Doebner reaction. We synthesized new 2-methylquinoline-4-carboxilic acid derivatives simply by stirring pyruvic acid and aromatic amine in ethanol with high purity. Generally, we found that aniline derivatives possessing electron donating groups are needed for the synthesis of 2-methylquinoline-4-carboxilic acid derivatives in ethanol. 1H-NMR data of products revealed that this reaction is regioseletive and ring closure occurs on the position with less steric hindrance. The order of mixing of the reactants plays a key role in determining the type of products in the Doebner reaction.

Synthesis and molecular dynamic simulation studies of novel N-(1-benzylpiperidin-4-yl) quinoline-4-carboxamides as potential acetylcholinesterase inhibitors

A new series of N-(1-benzylpiperidin-4-yl) quinoline-4-carboxamide derivatives was designed and synthesized as potential acetylcholinesterase inhibitors. The compounds were characterized by nuclear magnetic resonance, infrared and mass spectrometry. In th

The Reaction of Pyruvic Acid with Amines and Aminoesters Rexamined

Phenylglicine esters react with pyruvic acid to give α-methylsuccinic amides 9 instead of the expected Schiff bases 8, analogously to p-anisidine but unlike aniline.