78554-91-3

Basic information

• Product Name: 2-{[(diethylamino)carbonyl]amino}-N,N-diethylbenzamide
• Synonyms: 2-{[(diethylamino)carbonyl]amino}-N,N-diethylbenzamide
• CAS NO: 78554-91-3
• Molecular Formula: C₁₆H₂₅N₃O₂
• Molecular Weight: 291.3886
• Mol File: 78554-91-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 491.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.088±0.06 g/cm3(Predicted)
• PKA: 14?+-.0.70(Predicted)
• CAS DataBase Reference: 2-{[(diethylamino)carbonyl]amino}-N,N-diethylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(diethylamino)carbonyl]amino}-N,N-diethylbenzamide(78554-91-3)
• EPA Substance Registry System: 2-{[(diethylamino)carbonyl]amino}-N,N-diethylbenzamide(78554-91-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 78554-91-3(Hazardous Substances Data)

Usage

Chemical category

Benzamides, which are commonly used as pharmaceuticals.

Physical form

A solid, white powder at room temperature.

Composition

Composed of a benzene ring attached to a carbonyl group and two diethylamino groups.

Pharmacological properties

Unique properties provided by the composition of the compound.

Common use

Used as a local anesthetic.

Potential applications

Studied for its potential in treating chronic pain and substance abuse/dependence.

Upstream product

• 57212-70-1 N-(mesyloxy)phthalimide 
• 109-89-7 diethylamine 

Downstream Products

• 233684-00-9 4-[2-(3,3-diethylureido)benzoyl]morpholine 
• 118-48-9 isatoic anhydride 
• 233684-03-2 N,N-diethyl-N'-(o-carboxyphenyl)urea 

Relevant articles and documents

One-Pot Reactions of N-(Mesyloxy)phthalimides with Secondary Amines to 2-Ureidobenzamides, 2-Ureidobenzoic Acids, Ethyl 2-Ureidobenzoates, or Isatoic Anhydrides

The reaction of N-(mesyloxy)phthalimides with secondary amines was examined. Transformations are accomplished by one-pot reactions to optionally afford corresponding 2-ureidobenzamides, 2-ureidobenzoic acids, ethyl 2-ureidobenzoates, or isatoic anhydrides, respectively. The mechanism of the acid-catalyzed hydrolysis (or alcoholysis) of intermediate 2-ureidobenzamides to 2-ureidobenzoic acids (or esters) is discussed. A proton transfer mechanism involving the ureido moiety as an internal acid catalyst is proposed. Intermediate 2-ureidobenzoic acids undergo a further transformation to isatoic anhydrides. The utilization of the obtained 2-ureidobenzamides, 2-ureidobenzoic acids, and ethyl 2-ureidobenzoates to prepare 3,1-benzoxazin-4-ones is demonstrated.