78561-69-0Relevant academic research and scientific papers
Nouvelle methode de preparation d'esters phosphoriques, renfermant un groupe β-mercaptoethyle, utilisables en synthese nucleotidique
Thuong, Nguyen Thanh,Chassignol, Marcel,Asseline, Ulysse,Chabrier, Pierre
, p. 51 - 56 (2007/10/02)
The 2-alkoxy-2-oxo-1,3,2-dioxaphospholanes are easy to prepare and react with thiolate anions, giving in good yields phosphodiesters carrying a β-mercaptoethyl group used as a protecting group.Application of this reaction to 5'-o-monomethoxytritylthymidine easily leads to the nucleoside 3'-phosphodiester from which fully protected TpT and TpTp have been prepared.
