78573-23-6

Basic information

• Product Name: Propanedioic acid, (4-phenylbutyl)-, diethyl ester
• CAS NO: 78573-23-6
• Molecular Formula: C17H24O4
• Molecular Weight: 292.375
• Mol File: 78573-23-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (4-phenylbutyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (4-phenylbutyl)-, diethyl ester(78573-23-6)
• EPA Substance Registry System: Propanedioic acid, (4-phenylbutyl)-, diethyl ester(78573-23-6)

Safety Data

• Hazardous Substances Data: 78573-23-6(Hazardous Substances Data)

Upstream product

• 996-82-7 sodium diethylmalonate 
• 768-56-9 4-Phenylbut-1-ene 
• 105-53-3 diethyl malonate 
• 3360-41-6 4-phenyl-butan-1-ol 
• 4830-93-7 1-Chloro-4-phenylbutane 
• 13633-25-5 1-Bromo-4-phenylbutane 
• 996-82-7 sodium diethylmalonate 
• 6921-34-2 benzylmagnesium chloride 

Downstream Products

• 716316-49-3 2-(4-phenylbutyl)-2-propargylmalonic acid diethyl ester 
• 1658497-46-1 C₁₁H₁₄FI 
• 1616365-94-6 (5-bromo-5-fluoropentyl)benzene 
• 5449-70-7 ethyl-(4-phenyl-butyl)-malonic acid 
• 861590-80-9 bromo-(4-phenyl-butyl)-malonic acid 
• 861579-76-2 2-bromo-6-phenyl-hexanoic acid 
• 36061-05-9 2-amino-6-phenylhexanoic acid 
• 1026039-32-6 4,6-diiodo-5-(4-phenyl-butyl)-pyrimidine 

Relevant articles and documents

Hydroalkylation of Unactivated Olefins via Visible-Light-Driven Dual Hydrogen Atom Transfer Catalysis

Radical hydroalkylation of olefins enabled by hydrogen atom transfer (HAT) catalysis represents a straightforward means to access C(sp3)-rich molecules from abundant feedstock chemicals without the need for prefunctionalization. While Giese-type hydroalkylation of activated olefins initiated by HAT of hydridic carbon-hydrogen bonds is well-precedented, hydroalkylation of unactivated olefins in a similar fashion remains elusive, primarily owing to a lack of general methods to overcome the inherent polarity-mismatch in this scenario. Here, we report the use of visible-light-driven dual HAT catalysis to achieve this goal, where catalytic amounts of an amine-borane and an in situ generated thiol were utilized as the hydrogen atom abstractor and donor, respectively. The reaction is completely atom-economical and exhibits a broad scope. Experimental and computational studies support the proposed mechanism and suggest that hydrogen-bonding between the amine-borane and substrates is beneficial to improving the reaction efficiency.

Cysteine derivatives as inhibitors for carboxypeptidase A: Synthesis and structure-activity relationships

A series of cysteine (Cys) derivatives having an alkyl or arylalkyl moiety on the α-amino group of the amino acid have been synthesized as a novel type of inhibitor for carboxypeptidase A. These compounds are readily prepared starting with Cys in an optic

beta -thiopropionyl-aminoacid derivatives and their use as beta -lactamase inhibitors

PCT No. PCT/EP97/00516 Sec. 371 Date Jan. 13, 1999 Sec. 102(e) Date Jan. 13, 1999 PCT Filed Feb. 3, 1997 PCT Pub. No. WO97/30027 PCT Pub. Date Aug. 21, 1997A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a beta -lactam antibiotic, a therapeutically effective amount of an amino acid derivative of Formula (I) or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: R is hydrogen, a salt forming cation or an in vivo hydrolysable ester-forming group; R1 is hydrogen, (C1-6)alkyl optionally substituted by up to three halogen atoms or by a mercapto, (C1-6)alkoxy, hydroxy, amino, nitro, carboxy, (C1-6)alkylcarbonyloxy, (C1-6)alkoxycarbonyl, formyl or (C1-6)alkylcarbonyl group, (C3-7)cycloalkyl, (C3-7)cycloalkyl(C2-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, aryl, aryl(C1-6)alkyl, heterocyclyl or heterocyclyl(C1-6)alkyl; R2 is hydrogen, (C1-6)alkyl or aryl(C1-6)alkyl; R3 is hydrogen, (C1-6)alkyl optionally substituted by up to three halogen atoms, (C3-7)cycloalkyl, fused aryl(C3-7)cycloalkyl, (C3-7)cycloalkyl(C2-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, aryl, aryl-(CHR10)m-X-(CHR11)n, heterocyclyl or heterocyclyl-(CHR10)m-X-(CHR11)n, where m is 0 to 3, n is 1 to 3, each R10 and R11 is independently hydrogen or (C1-4)alkyl and X is O, S(O)x where x is 0-2, or a bond; R4 is hydrogen, or an in vivo hydrolysable acyl group; and R5 and R6 are independently hydrogen and (C1-6)alkyl or together represent (CH2)p where p is 2 to 5. Some compounds are claimed per se.