785795-46-2Relevant academic research and scientific papers
Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction
Jennings, Lee D.,Foreman, Kenneth W.,Rush III, Thomas S.,Tsao, Desiree H.H.,Mosyak, Lidia,Kincaid, Scott L.,Sukhdeo, Mohani N.,Sutherland, Alan G.,Ding, Weidong,Kenny, Cynthia Hess,Sabus, Chantel L.,Liu, Hanlan,Dushin, Elizabeth G.,Moghazeh, Soraya L.,Labthavikul, Pornpen,Petersen, Peter J.,Tuckman, Margareta,Ruzin, Alexey V.
, p. 5115 - 5131 (2007/10/03)
The ZipA-FtsZ protein-protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were demonstrat
