78585-58-7Relevant academic research and scientific papers
N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
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Page/Page column 88; 89, (2018/03/25)
The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
Gold(I)- and Yb(OTf)3-Cocatalyzed rearrangements of epoxy alkynes: Transfer of a carbonyl group in a five-membered carbocycle
Dai, Lun-Zhi,Shi, Min
supporting information; experimental part, p. 2496 - 2502 (2010/06/20)
We report here the intramolecular reactions between α,β-epoxy ketones and alkynes cocatalyzed by gold(I) and Yb(OTf)3. This new catalytic system based on a combination of gold(I) and Yb (OTf)3 allows facile transformation of epoxy alkynes to give novel indene derivatives in moderate to good yields under mild conditions. Moreover, we describe here the first observation of a transfer of a carbonyl group in a five-membered carbocycle during gold-catalyzed reactions. This proposed mechanism is corroborated by isotope-labeling experiments (D and 13C). Furthermore, the probable role of each catalyst in this interesting domino reaction has been examined by 31P NMR experiments. The utilization of gold catalysts combined with rareearth metal salts offers a new concept for the design of catalyst combinations for domino or cascade reactions.
Stereoselective synthesis of rubrenoic and nor-rubrenoic acids
Sanchez, Lucina G.,Castillo, Elizabeth N.,Maldonado, Hortensia,Chavez, Daniel,Somanathan, Ratnasamy,Aguirre, Gerardo
, p. 54 - 71 (2008/03/14)
The total stereoselective synthesis of (Z)-rubrenoic I (1a), (Z)-nor-rubrenoic I (17a), (E)-rubrenoic III (3b), and nor-(E)-rubrenoic III (30b) acids was achieved using Suzuki and Stille cross-coupling reactions from readily available starting materials.
Determination of the Heats of Formation of the Isomeric Xylylenes by Ion Cyclotron Double-Resonance Spectroscopy
Pollack, Steven K.,Raine, Brian C.,Hehre, Warren J.
, p. 6308 - 6313 (2007/10/02)
Heats of formation of 50 and 53 kcal mol -1 have been measured for p- and o-xylylene by using pulsed-ion cyclotron double-resonance spectroscopy.In addition a lower bound of 76 kcal mol-1 has been obtained for the heat of formation o
