78602-27-4

Upstream product

• 100-44-7 benzyl chloride 
• 6630-33-7 ortho-bromobenzaldehyde 
• 6921-34-2 benzylmagnesium chloride 
• 18982-54-2 o-bromobenzyl alcohol 
• 1589-82-8 phenylmagnesium bromide 

Downstream Products

• 36081-66-0 2'-bromo-2-phenylacetophenone 
• 78602-28-5 1-bromo-2-(2-phenylethenyl)benzene 
• 883-20-5 9-methylphenanthrene 
• 7011-98-5 3-benzyl-3H-isobenzofuran-1-one 
• 57918-64-6 1-(2-bromophenyl)-2-phenylethane 
• 54737-45-0 (E)-2-bromostilbene 

Relevant academic research and scientific papers

Br?nsted Acid-Catalyzed Carbonyl-Olefin Metathesis: Synthesis of Phenanthrenes via Phosphomolybdic Acid as a Catalyst

Compared with the impressive achievements of catalytic carbonyl-olefin metathesis (CCOM) mediated by Lewis acid catalysts, exploration of the CCOM through Br?nsted acid-catalyzed approaches remains quite challenging. Herein, we disclose a synthetic protocol for the construction of a valuable polycycle scaffold through the CCOM with the inexpensive, nontoxic phosphomolybdic acid as a catalyst. The current annulations could realize carbonyl-olefin, carbonyl-alcohol, and acetal-alcohol in situ CCOM reactions and feature mild reaction conditions, simple manipulation, and scalability, making this strategy a promising alternative to the Lewis acid-catalyzed COM reaction.

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Asymmetric Synthesis of 1,2-Dihydronaphthalene-1-ols via Copper-Catalyzed Intramolecular Reductive Cyclization

We describe a copper-catalyzed intramolecular reductive cyclization of easily accessible benz-tethered 1,3-dienes containing a ketone moiety. This process provided biologically active 1,2-dihydronaphthalene-1-ol derivatives in good yields with excellent enantio- and diastereoselectivity. Mechanistic investigations using density functional theory revealed that (Z)- and (E)-allylcopper intermediates formed in situ from the diene and copper catalyst undergo isomerization and selective intramolecular allylation of the (E)-allylcopper form of the major product through a six-membered boatlike transition state. The resulting products were further transformed to fully saturated naphthalene-1-ols by reactions of the olefin moiety.

Palladium-catalyzed oxidative activation of arylcyclopropanes

(Diagram presented) Palladium chloride-catalyzed intramolecular activation of electroneutral cyclopropane derivatives results in cleavage of the cyclopropane ring followed by formation of heterocyclic derivatives. Phenols, carboxylic acids, and amide groups were considered as substituents ortho to the cyclopropane ring in this catalytic activation chemistry. The regioselectivity observed in the case of amide-containing substrates was different from that of carboxylic acid-containing substrates, ruling out simple cyclopropane isomerization followed by a Wacker oxidation as the mechanistic pathway.

BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE

Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.

Iminyls. Part 9. Intramolecular Addition of an Iminyl to an Alkene

Phenyl o-styrylphenyl iminyl, generated by oxidation of the corresponding O-carboxymethyloxime with persulphate and by thermolysis of the perester of that acid, cyclises to give a mixture of isoquinoline and 1H-isoindole derivatives.The intermediate radicals have been investigated by e.s.r.