7011-98-5Relevant articles and documents
Manganese- and Borane-Mediated Synthesis of Isobenzofuranones from Aromatic Esters and Oxiranes via C-H Bond Activation
Sueki, Shunsuke,Wang, Zijia,Kuninobu, Yoichiro
, p. 304 - 307 (2016)
A manganese- and borane-mediated synthesis of isobenzofuranones from esters and oxiranes is developed. The reaction proceeded at aromatic, heteroaromatic, and olefinic C-H bonds with high functional group tolerance. This is the first example of a manganese-catalyzed C-H transformation using an oxygen-directing group. Triphenylborane played an important role in this reaction to cooperatively promote the annulation reaction. Kinetic isotope effect experiments revealed that C-H bond activation of the aromatic rings was the rate-determining step.
Titanocene(III) chloride mediated radical induced synthesis of isobenzofuranones via allylation of aldehydes followed by in situ lactonization
Mukherjee, Shirshendu,Roy, Subhas Chandra
, p. 85 - 90 (2019/05/21)
Titanocene(III) chloride mediated radical induced synthesis of isobenzofuranones has been accomplished via allylation of aldehydes followed by in situ lactonization in good yield. The radical initiator titanocene(III) chloride (Cp2TiCl) has been prepared from commercially available Cp2TiCl2 and Zn dust in THF under argon.
Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1(3H)-ones
Mahendar, Lodi,Satyanarayana, Gedu
, p. 7685 - 7691 (2016/09/09)
An efficient domino [Pd]-catalysis for the synthesis of isobenzofuran-1(3H)-ones is presented. The strategy shows broad substrate scope and is amenable to o-bromobenzyl tertiary/secondary/primary alcohols. Significantly, the method was applied to the synthesis of antiplatelet drug n-butyl phthalide and cytotoxic agonist 3a-[4′-methoxylbenzyl]-5,7-dimethoxyphthalide.
