78628-28-1

Basic information

• Product Name: Roxatidine acetate
• Synonyms: ROXATIDINE ACETATE;2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-acetamid;2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)acetamide;aceroxatidine;3-[3-(1-piperidylmethyl)phenoxy]propylcarbamoylmethyl acetate;2-(Acetyloxy)-N-[3-[3-(1-piperidinylmethyl)l~henoxy]19ropyl]acetamide;Altat：TZU-0460;Gastralgin：Roxit
• CAS NO: 78628-28-1
• Molecular Formula: C₁₉H₂₈N₂O₄
• Molecular Weight: 348.43662
• Mol File: 78628-28-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 59-60°
• Boiling Point: 537.3 °C at 760 mmHg
• Flash Point: 278.7 °C
• Appearance: white or off-white powder
• Density: 1.13 g/cm³
• Vapor Pressure: 1.29E-11mmHg at 25°C
• Refractive Index: 1.532
• Storage Temp.: 2-8°C
• PKA: 14.23±0.46(Predicted)
• CAS DataBase Reference: Roxatidine acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Roxatidine acetate(78628-28-1)
• EPA Substance Registry System: Roxatidine acetate(78628-28-1)

Safety Data

• Hazardous Substances Data: 78628-28-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23)

Upstream product

• 101650-46-8 1-chloro-3-{3-[(piperidin-1-yl)methyl]phenoxy}propane 
• 73279-04-6 3-[1-piperidinylmethyl]phenol 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 127-09-3 sodium acetate 
• 127-08-2 potassium acetate 
• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 50-00-0 formaldehyd 

Relevant articles and documents

Synthesis method of roxatidine acetate

The invention provides a preparation method of Roxatidine acetate, wherein the chemical name of the Roxatidine acetate is 2-acetoxy-N-[3-[3-(1-piperidinyl methyl) phenoxy] propyl] acetamide (formula VI). The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, high yield, simple post-treatment operation, green and environment-friendly solvent reagent and the like, reduces the cost, has certain technical advantages, is environment-friendly, and is suitable for large-scale industrial production.