78632-96-9Relevant academic research and scientific papers
Synthesis of oligosaccharide determinants with amide spacers of T-type antigens
Paulsen,Jacquinet,Rust
, p. 195 - 219 (2007/10/02)
The hapten of the T-antigen was synthesized with a peptide-like amide-spacer as 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside and coupled with serum albumin to give a synthetic antigen. Other O-beta-D-galactopyranosyl haptens, 2-(4-methoxycarbonylbutanecarboxamido)ethyl 2-acetamido-2-deoxy-4-O-beta-D-galactopyranosyl-alpha-D-galactopyranoside, O-beta-D-galactopyranosyl-(1 leads to 3)-O-[beta-D-galactopyranosyl-(1 leads to 4)]-2-acetamido-2-deoxy-alpha-D-galactopyranoside, and 2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-glucopyranoside, the last compound being the determinant of the Lewis Lec antigen, were also synthesized.
SYNTHESE VON OLIGOSACCHARID-DETERMINANTEN DES T-ANTIGENS MIT AMID-SPACER ZUR DARSTELLUNG SYNTHETISCHER ANTIGENE
Jacquinet, Jean-Claude,Paulsen, Hans
, p. 1387 - 1390 (2007/10/02)
The β(1->3)-linked disaccharide 15 was synthesized from D-galactose and D-galactosamine unit with a watersoluble amide spacer.This represents the hapten of T-antigen and, when coupled to a protein, is suitable for use as an artificial antigen.Other O-β-D-
