78731-92-7Relevant academic research and scientific papers
Facile synthesis of a "ready to use" precursor of porphobilinogen and its amino acid derivatives
Soldermann, Carole Pissot,Vallinayagam, Ramakrishnan,Tzouros, Manuel,Neier, Reinhard
, p. 764 - 767 (2008/09/18)
(Chemical Equation Presented) A practical synthesis of porphobilinogen based on the biosynthetic mechanism is described. The crossed Mukayiama aldol reaction is the key step creating the central carbon-carbon bond between the two protected forms of 5-aminolevulinic acids. The optimized sequence gives a crystalline, storable precursor, which can be transformed in high yield into porphobilinogen and bioconjugates thereof. The enzymatic hydrolysis of the precursor produces porphobilinogen in quantitative yield.
THE SYNTHESIS OF SELECTIVELY PROTECTED β-DIKETONES AND β-KETOALDEHYDES
Kraus, George A.,Shimagaki, Masayuki
, p. 1171 - 1174 (2007/10/02)
The reaction of acyl cyanides with enol silyl ethers produces β-cyano, β-hydroxy carbonyl compounds.
