787563-23-9

Basic information

• Product Name: 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester
• Synonyms: 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester
• CAS NO: 787563-23-9
• Molecular Weight: 293.325
• Mol File: 787563-23-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester(787563-23-9)
• EPA Substance Registry System: 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester(787563-23-9)

Safety Data

• Hazardous Substances Data: 787563-23-9(Hazardous Substances Data)

Upstream product

• 32683-00-4 ethyl 2-phenylimidazole-4-carboxylate 
• 15854-87-2 4-iodopyridine 
• 77498-98-7 2-phenyl-1H-imidazole-4-carboxylic acid 
• 33469-36-2 2-phenyl-4-(trifluoromethyl)-1H-imidazole 
• 100-52-7 benzaldehyde 
• 504-24-5 4-aminopyridine 
• 100-47-0 benzonitrile 
• 787563-22-8 N-(4-pyridyl)benzamidine 

Downstream Products

• 787563-21-7 2-phenyl-1-(pyridin-4-yl)-1H-imidazole-4-carboxylic acid 

Relevant articles and documents

Imidazole-derived agonists for the neurotensin 1 receptor

A scaffold-hop program seeking full agonists of the neurotensin-1 (NTR1) receptor identified the probe molecule ML301 (1) and associated analogs, including its naphthyl analog (14) which exhibited similar properties. Compound 1 showed full agonist behavior (79-93%) with an EC50 of 2.0-4.1 μM against NTR1. Compound 1 also showed good activity in a Ca mobilization FLIPR assay (93% efficacy at 298 nM), consistent with it functioning via the G q coupled pathway, and good selectivity relative to NTR2 and GPR35. In further profiling, 1 showed low potential for promiscuity and good overall pharmacological data. This report describes the discovery, synthesis, and SAR of 1 and associated analogs. Initial in vitro pharmacologic characterization is also presented.