32683-00-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-phenyl-imidazole-4-carboxylate is used as a building block for the synthesis of various pharmaceuticals due to its imidazole structure, which is a common feature in many bioactive compounds. Its presence in drug development can contribute to the creation of new medications with diverse therapeutic applications.
Used in Organic Chemistry:
In the field of organic chemistry, Ethyl 2-phenyl-imidazole-4-carboxylate serves as a versatile intermediate for the synthesis of a wide range of organic compounds. Its reactivity and functional groups make it suitable for various chemical reactions, facilitating the production of complex organic molecules.
Used in Agricultural Chemicals Production:
Ethyl 2-phenyl-imidazole-4-carboxylate is used as a precursor in the production of agricultural chemicals. Its chemical properties allow it to be incorporated into the structures of pesticides, herbicides, and other agrochemicals, enhancing their effectiveness in crop protection.
Used in Dye Industry:
In the dye industry, Ethyl 2-phenyl-imidazole-4-carboxylate is utilized for the synthesis of various dyes. Its imidazole structure contributes to the color and stability of the dyes, making it a valuable component in the development of new dye products for textiles, printing, and other applications.

InChI:InChI=1/C12H12N2O2/c1-2-16-12(15)10-8-13-11(14-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H,13,14)

Upstream product

• 6829-40-9 aminomalonic acid diethyl ester 
• 77498-98-7 2-phenyl-3H-imidazole-4-carboxylic acid 
• 1369937-41-6 C₁₂H₁₄N₂O₂ 
• 98-88-4 benzoyl chloride 
• 495-69-2 Hippuric Acid 
• 1199-01-5 2-phenylazlactone 
• 623-49-4 ethyl cyanoformate 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 623-47-2 propynoic acid ethyl ester 
• 33469-36-2 2-phenyl-4-(trifluoromethyl)-1H-imidazole 
• 100-52-7 benzaldehyde 
• 77498-98-7 2-phenyl-1H-imidazole-4-carboxylic acid 
• 64-17-5 ethanol 
• 37126-46-8 ethyl 5-diazo-2-phenylimidazole-4-carboxylate 

Downstream Products

• 787563-21-7 2-phenyl-1-(pyridin-4-yl)-1H-imidazole-4-carboxylic acid 
• 787563-23-9 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester 
• 77498-98-7 2-phenyl-3H-imidazole-4-carboxylic acid 
• 86119-60-0 N-methyl-2-phenyl-4-carbethoxyimidazole 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

SUBSTITUTED HETEROCYCLES AS BROMODOMAIN INHIBITORS

The present application relates to substituted heterocycles compound of Formula I and pharmaceutical compositions thereof useful for the inhibition of BET protein function by binding to bromodomains (Formula I).

Imidazole-derived agonists for the neurotensin 1 receptor

A scaffold-hop program seeking full agonists of the neurotensin-1 (NTR1) receptor identified the probe molecule ML301 (1) and associated analogs, including its naphthyl analog (14) which exhibited similar properties. Compound 1 showed full agonist behavior (79-93%) with an EC50 of 2.0-4.1 μM against NTR1. Compound 1 also showed good activity in a Ca mobilization FLIPR assay (93% efficacy at 298 nM), consistent with it functioning via the G q coupled pathway, and good selectivity relative to NTR2 and GPR35. In further profiling, 1 showed low potential for promiscuity and good overall pharmacological data. This report describes the discovery, synthesis, and SAR of 1 and associated analogs. Initial in vitro pharmacologic characterization is also presented.

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Highly efficient oxidation of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives by dioxygen

A highly efficient and environmental-benign oxidation by dioxygen (or air) as the sole oxidant was first applied for the conversion of 2-imidazoline-5- carboxylic derivatives to imidazole-5-carboxylic derivatives in very good and excellent yields. The sub

Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds

(Chemical Equation Presented) Carbenes derived from diazoimidazolecarboxylates 4 under thermal or photochemical conditions undergo O-H and N-H insertion reactions with alcohols and amines, respectively, in moderate yield, in competition with reduction in good H-donor solvents. Dichloromethane reacts to give the corresponding 4-chloroimidazole. Aromatic hydrocarbons are excellent traps for the imidazolylidene carbene and lead to a range of arylimidazole derivatives 7. Reaction with pyridine leads to the first example of a pyridinium ylide 8 formed from an imidazolylidene carbene, whereas irradiation in hexafluorobenzene gives the imidazoazocine 11, presumably by way of an initial norcaradiene intermediate.

CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin-resistant improver, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula (I), a salt thereof, an ester thereof or a hydrate of them. In the formula, R1 represents hydrogen atom, hydroxyl group or a C1-6 alkyl group etc. which may have one or more substituents; L represents a single or double bond or a C1-6 alkylene group etc. which may have one or more substituents; M represents a single bond or a C1-6 alkylene group etc. which may have one or more substituents; T represents a single bond or a C1-3 alkylene group which may have one or more substituents; W represents carboxyl group or a group represented by the formula -CON(Rw1)Rw2 (wherein Rw1 and Rw2 are the same as or different from each other and each represents hydrogen atom, formyl group etc.) etc.; represents a single or double bond; X represents oxygen atom or a C2-6 alkenylene group etc. which may have one or more substituents; Y represents a C5-12 aromatic hydrocarbon group etc. which may have one or more substituents and which may have one or more heteroatoms; and ring Z represents a C5-6 aromatic hydrocarbon group which may have 0 to 4 substituents and which may have one or more heteroatoms.

SYNTHESIS OF IMIDAZOLE DERIVATIVES FROM α-HALOOXIMES AND AMIDINES BY USE OF IRON CARBONYLS

The reaction of α-halooximes with amidines in the presence of iron carbonyls gives imidazole derivatives in good yields.This reaction occurs via deoxygenation of 4H-1,2,5-oxadiazines by iron carbonyls.