32683-00-4

Basic information

• Product Name: ETHYL 2-PHENYL-IMIDAZOLE-4-CARBOXYLATE
• Synonyms: RARECHEM AL BI 1033;ETHYL 2-PHENYL-IMIDAZOLE-4-CARBOXYLATE;2-Phenyl-1H-imidazole-5-carboxylic acid ethyl ester;2-Phenylimidazole-5-carboxylic acid ethyl ester;Ethyl 2-phenyl-1H-iMidazole-5-carboxylate;2-phenyl-Imidazole-4-carboxylic acid ethyl ester
• CAS NO: 32683-00-4
• Molecular Formula: C₁₂H₁₂N₂O₂
• Molecular Weight: 216.24
• Product Categories: pharmacetical
• Mol File: 32683-00-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 210℃
• Boiling Point: 413.8 °C at 760 mmHg
• Flash Point: 204 °C
• Appearance: /
• Density: 1.196
• Vapor Pressure: 4.68E-07mmHg at 25°C
• Refractive Index: 1.575
• PKA: 11.09±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-PHENYL-IMIDAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-PHENYL-IMIDAZOLE-4-CARBOXYLATE(32683-00-4)
• EPA Substance Registry System: ETHYL 2-PHENYL-IMIDAZOLE-4-CARBOXYLATE(32683-00-4)

Safety Data

• Hazardous Substances Data: 32683-00-4(Hazardous Substances Data)

Usage

General Description

Ethyl 2-phenyl-imidazole-4-carboxylate is a chemical compound with the molecular formula C12H12N2O2. It is an imidazole derivative and belongs to the class of esters. Ethyl 2-phenyl-imidazole-4-carboxylate is commonly used as a building block in the synthesis of various pharmaceuticals and organic compounds. It is also used as a precursor in the production of agricultural chemicals and dyes. Ethyl 2-phenyl-imidazole-4-carboxylate exhibits pharmacological and biological activities, making it a valuable component in the development of new drugs and chemical compounds. However, it is important to handle this chemical with care, as it may pose health and safety risks if not properly handled and stored.

InChI:InChI=1/C12H12N2O2/c1-2-16-12(15)10-8-13-11(14-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H,13,14)

Upstream product

• 37126-46-8 ethyl 5-diazo-2-phenylimidazole-4-carboxylate 
• 67-63-0 isopropyl alcohol 
• 77498-98-7 2-phenyl-1H-imidazole-4-carboxylic acid 
• 64-17-5 ethanol 
• 100-52-7 benzaldehyde 
• 33469-36-2 2-phenyl-4-(trifluoromethyl)-1H-imidazole 
• 98-88-4 benzoyl chloride 
• 495-69-2 Hippuric Acid 
• 1199-01-5 2-phenylazlactone 
• 623-49-4 ethyl cyanoformate 
• 613-92-3 N-hydroxybenzenecarboximidamide 
• 623-47-2 propynoic acid ethyl ester 
• 127033-04-9 ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate 
• 57767-07-4 N-methyl-N-phenylbenzimidamide 

Downstream Products

• 787563-21-7 2-phenyl-1-(pyridin-4-yl)-1H-imidazole-4-carboxylic acid 
• 787563-23-9 2-phenyl-1-(4-pyridyl)-1H-imidazole-4-carboxylic acid ethyl ester 
• 77498-98-7 2-phenyl-3H-imidazole-4-carboxylic acid 
• 86119-60-0 N-methyl-2-phenyl-4-carbethoxyimidazole 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Imidazole-derived agonists for the neurotensin 1 receptor

A scaffold-hop program seeking full agonists of the neurotensin-1 (NTR1) receptor identified the probe molecule ML301 (1) and associated analogs, including its naphthyl analog (14) which exhibited similar properties. Compound 1 showed full agonist behavior (79-93%) with an EC50 of 2.0-4.1 μM against NTR1. Compound 1 also showed good activity in a Ca mobilization FLIPR assay (93% efficacy at 298 nM), consistent with it functioning via the G q coupled pathway, and good selectivity relative to NTR2 and GPR35. In further profiling, 1 showed low potential for promiscuity and good overall pharmacological data. This report describes the discovery, synthesis, and SAR of 1 and associated analogs. Initial in vitro pharmacologic characterization is also presented.

Highly efficient oxidation of 2-imidazoline-5-carboxylic derivatives to imidazole-5-carboxylic derivatives by dioxygen

A highly efficient and environmental-benign oxidation by dioxygen (or air) as the sole oxidant was first applied for the conversion of 2-imidazoline-5- carboxylic derivatives to imidazole-5-carboxylic derivatives in very good and excellent yields. The sub