78759-36-1

Upstream product

• 78759-34-9 trans-4-Cyano-5-nitro-trans-3-phenyl-N-tert-butylisoxazolidine 
• 78759-34-9 (3S,4R,5S)-2-tert-Butyl-5-nitro-3-phenyl-isoxazolidine-4-carbonitrile 
• 3376-24-7 N-tert-butyl-α-phenylnitrone 
• 6852-58-0 N-benzylidene tert-butylamine 
• 87352-00-9 (Z)-3-chloro-3-cyano-N-tert-butyl-4-phenyl-2-azetidinone 
• 78759-35-0 trans-5-cyano-4-nitro-3-phenyl-N-tert-butylisoxazolidine 
• 78759-38-3 1-tert-Butyl-3-chloro-2-oxo-4-phenyl-azetidine-3-carbonitrile 
• 78759-37-2 trans-N-tert-butyl-3-cyano-4-phenyl-2-azetidinone 

Downstream Products

• 78759-37-2 trans-N-tert-butyl-3-cyano-4-phenyl-2-azetidinone 

Relevant academic research and scientific papers

New Synthesis of β-Lactams Based on Nitrone Cycloaddition to Nitroalkenes

Heating a sample of the major 5-nitro-substituted isoxazolidine isomer obtained from the reaction of a C-phenyl-N-alkylnitrone with trans-1-cyano-2-nitroethylene in methanol resulted in ring contraction and formation of 4-phenyl-3-cyano-N-alkyl-2-azetidin

NEW APPLICATIONS OF DIPOLAR CYCLOADDITION CHEMISTRY TOWARD THE SYNTHESIS OF HETEROCYCLES

A new method for the preparation of β-lactams has been developed.The protocol involves 1,3-dipolar cycloaddition of nitrones with nitro substituted alkenes followed by a subsequent reorganization of the resulting 5-nitroisoxazolidine isomer.The utilizatio